Debulking surgery after muscular paraffin oil injections: Effects on calcium homeostasis and patient satisfaction

Cosmetic paraffin oil injections can lead to granuloma formation causing hypercalcemia and kidney failure. This study explores whether debulking surgery is an effective treatment for improving calcium homeostasis, inflammation and clinical symptoms. In a retrospective study, we reviewed 33 patients...

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Published in:The journal of clinical endocrinology and metabolism 2024-09
Main Authors: Yahyavi, Sam Kafai, Wall-Gremstrup, Gustav, Makki, Ahmad, Juel, Jacob, Theilade, Simone, Berg, Jais Oliver, Juul, Anders, Momsen, Ole, Eldrup, Ebbe, Blomberg Jensen, Martin
Format: Article
Language:English
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Summary:Cosmetic paraffin oil injections can lead to granuloma formation causing hypercalcemia and kidney failure. This study explores whether debulking surgery is an effective treatment for improving calcium homeostasis, inflammation and clinical symptoms. In a retrospective study, we reviewed 33 patients undergoing debulking surgery. Changes in calcium, inflammatory markers, and renal function from baseline up to twelve months post-surgery were assessed. Patients were interviewed post-surgery. The patients were 34.6 years (SD 6.9) and had 1,104 grams (SD 591) of granuloma tissue removed following injection of 1,329 mL (SD 803) paraffin oil 7.9 years (SD 3.2) earlier. Seventeen patients had hypercalcemia and experienced a significant decline in ionized calcium from 1.48 mmol/L (SD 0.16) at baseline to 1.33 mmol/L (SD 0.03) at twelve months (p
ISSN:0021-972X
1945-7197
1945-7197
DOI:10.1210/clinem/dgae606