Effect of irisin on ovarian phosphatidylinositol‐3‐kinase/protein kinase B signaling pathway and mitogen‐activated protein kinase/extracellular signal‐regulated kinase pathways of rats with polycystic ovary syndrome

Objective To investigate the independent effects of irisin on insulin resistance (IR) in ovary of polycystic ovary syndrome (PCOS) and explore possible pathways. Methods We established PCOS medel using Poretsky L's method, then PCOS rats were randomly divided into model group (M) and irisin gro...

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Published in:The journal of obstetrics and gynaecology research 2024-10, Vol.50 (10), p.1945-1951
Main Authors: Li, Cheng‐gang, Zhou, Li, Zhang, Ying‐jun, Li, Yong, Zhao, Li‐yan
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Blood levels
Extracellular signal-regulated kinase
Fasting
Homeostasis
Insulin resistance
irisin
Kinases
MAP kinase
MAPK/ERK pathway
Metabolic pathways
mRNA
Optical density
Ovaries
PI3K/AKT pathway
polycystic ovarian syndrome
Polycystic ovary syndrome
Signal transduction
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Summary:Objective To investigate the independent effects of irisin on insulin resistance (IR) in ovary of polycystic ovary syndrome (PCOS) and explore possible pathways. Methods We established PCOS medel using Poretsky L's method, then PCOS rats were randomly divided into model group (M) and irisin group (I), and normal rats (N) were used as the control. Then rats in the group I were injected with recombinant irisin. Then the levels of circulating fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of IR (HOMA‐IR) and PI3K/AKT and MAPK/ERK pathways in each group were observed, as well as the effects of irisin on the levels of circulating HOMA‐IR and PI3K/AKT and MAPK/ERK pathways in ovary of PCOS rats were evaluated. Results Compared with normal group, levels of FBG, FINS, and HOMA‐IR of model group were significantly increased (p 
ISSN:1341-8076
1447-0756
1447-0756
DOI:10.1111/jog.16076