Amygdala connectivity is associated with withdrawn/depressed behavior in a large sample of children from the Adolescent Brain Cognitive Development (ABCD) Study

• Published in: Psychiatry research. Neuroimaging 2024-10, Vol.344, p.111877, Article 111877
• Main Authors: Thomas, Elina, Juliano, Anthony, Owens, Max, Cupertino, Renata B., Mackey, Scott, Hermosillo, Robert, Miranda-Dominguez, Oscar, Conan, Greg, Ahmed, Moosa, Fair, Damien A., Graham, Alice M., Goode, Nicholas J., Kandjoze, Uapingena P., Potter, Alexi, Garavan, Hugh, Albaugh, Matthew D.
• Format: Article
• Language: English
• Subjects: ABCD study; Amygdala connectivity; Depression; Internalizing; Resting-state fMRI; Social behaviors
• ISSN: 0925-4927; 1872-7506; 1872-7506
• DOI: 10.1016/j.pscychresns.2024.111877

•Left amygdala connections linked to withdrawn/depressed (w/d) behaviors in a large sample of children from the ABCD study.•Left amygdala connections to an auditory network region linked to w/d behaviors.•Left amygdala connections to dorsal attention network regions linked to w/d behaviors.•Left amygdala connections to a frontoparietal network region linked to w/d behaviors•Social behaviors were linked to amygdala connections associated with w/d behaviors. Many psychopathologies tied to internalizing symptomatology emerge during adolescence, therefore identifying neural markers of internalizing behavior in childhood may allow for early intervention. We utilized data from the Adolescent Brain and Cognitive Development (ABCD) Study® to evaluate associations between cortico-amygdalar functional connectivity, polygenic risk for depression (PRSD), traumatic events experienced, internalizing behavior, and internalizing subscales: withdrawn/depressed behavior, somatic complaints, and anxious/depressed behaviors. Data from 6371 children (ages 9–11) were used to analyze amygdala resting-state fMRI connectivity to Gordon parcellation based whole-brain regions of interest (ROIs). Internalizing behaviors were measured using the parent-reported Child Behavior Checklist. Linear mixed-effects models were used to identify patterns of cortico-amygdalar connectivity associated with internalizing behaviors. Results indicated left amygdala connections to auditory, frontoparietal network (FPN), and dorsal attention network (DAN) ROIs were significantly associated with withdrawn/depressed symptomatology. Connections relevant for withdrawn/depressed behavior were linked to social behaviors. Specifically, amygdala connections to DAN were associated with social anxiety, social impairment, and social problems. Additionally, an amygdala connection to the FPN ROI and the auditory network ROI was associated with social anxiety and social problems, respectively. Therefore, it may be important to account for social behaviors when looking for brain correlates of depression.