A Case of Spontaneous Regression of Adult Multi-system Langerhans Cell Histiocytosis Presenting as Liver Tumor Rupture

Adult multisystem Langerhans cell histiocytosis (MS-LCH) is rare and has a poor prognosis. A 67-year-old man with MS-LCH presented with a hepatic tumor rupture and multiple masses in the lungs, liver, and pancreas. Despite the initial aggressive disease course and involvement of organs at risk, the...

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Bibliographic Details
Published in:Internal Medicine 2024, pp.4060-24
Main Authors: Oshima, Seigi, Inano, Shojiro, Honjo, Gen, Tabata, Sumie, Fujimoto, Masakazu, Haga, Hironori, Kitano, Toshiyuki
Format: Article
Language:English
Subjects:
multi-system Langerhans cell histiocytosis
rupture of liver tumor
smoking cessation
spontaneous regression
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Summary:Adult multisystem Langerhans cell histiocytosis (MS-LCH) is rare and has a poor prognosis. A 67-year-old man with MS-LCH presented with a hepatic tumor rupture and multiple masses in the lungs, liver, and pancreas. Despite the initial aggressive disease course and involvement of organs at risk, the patient experienced spontaneous regression and lesion disappearance following smoking cessation without chemotherapy. A literature review revealed a distinct subset of MS-LCH that can be managed by smoking cessation and careful observation through follow-up imaging. This suggests that careful observation through follow-up imaging may be a reasonable alternative to chemotherapy in select adult cases of MS-LCH.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.4060-24