Simultaneous determination of cucurbitacins B, D, and E in Cucurbita seed oils by HPLC-DAD

Cucurbitacins are triterpene bioactive constituents of natural products, particularly in the Cucurbitaceae plant family. The presence of cucurbitacins in seeds of the genus (pumpkin) has been only little studied. In this work, the content of cucurbitacins B, D, and E in seed oils from three cucurbit...

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Published in:Natural product research 2024-09, p.1-7
Main Authors: Goya-Jorge, Elizabeth, Jorge-Rodríguez, María Elisa, Saucedo-Hernández, Yanelis
Format: Article
Language:English
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Summary:Cucurbitacins are triterpene bioactive constituents of natural products, particularly in the Cucurbitaceae plant family. The presence of cucurbitacins in seeds of the genus (pumpkin) has been only little studied. In this work, the content of cucurbitacins B, D, and E in seed oils from three cucurbits ( Duch, Linn, and Linn) was studied. An analytical method based on HPLC-DAD for the detection and quantification of these three cucurbitacins in seed oils was developed and validated according to ICH guidelines. The method showed good linearity, accuracy, and precision for the simultaneous quantification of cucurbitacins B, D, and E using seed oil as a reference. When applied to and seed oils, cucurbitacin B and D were quantified but to a lesser extent. This is the first report of a simple, repeatable, and reproducible analytical tool to identify cucurbitacins in oilseeds from spp.
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2024.2394097