Prognostic value of hyperlactatemia and lactate clearance in septic patients with hematological malignancies

Background The coexistence of sepsis and hematological malignancies increases patient vulnerability, revealing the need for precise prognostic markers. This study explores the prognostic significance of lactate levels and clearance in septic patients with hematological malignancies. Materials and me...

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Bibliographic Details
Published in:Annals of hematology 2024-10, Vol.103 (10), p.4239-4245
Main Authors: Inci, Kamil, Aygencel, Gülbin, Gökçe, Onur, Türkoğlu, Melda, Aydın Kaynar, Lale, Can, Ferda, Yeğin, Zeynep Arzu, Özkurt, Zübeyde Nur, Yağcı, Abdullah Münci
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Hematologic Neoplasms - blood
Hematologic Neoplasms - complications
Hematologic Neoplasms - mortality
Hematology
Hospital Mortality
Humans
Hyperlactatemia - blood
Hyperlactatemia - diagnosis
Hyperlactatemia - etiology
Intensive care
Intensive Care Units
Lactic Acid - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Mortality
Oncology
Prognosis
Retrospective Studies
Sepsis
Sepsis - blood
Sepsis - complications
Sepsis - diagnosis
Sepsis - mortality
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Summary:Background The coexistence of sepsis and hematological malignancies increases patient vulnerability, revealing the need for precise prognostic markers. This study explores the prognostic significance of lactate levels and clearance in septic patients with hematological malignancies. Materials and methods A retrospective cohort study from January 2016 to December 2019 in a tertiary hematological intensive care unit (ICU) included 167 adults with hematological malignancies and sepsis. The relationship between lactate levels, hyperlactatemia, lactate clearance, and ICU outcomes was investigated. ICU survivors and non-survivors were compared to identify the factors affecting ICU mortality. Results Patients were primarily with lymphoma and acute leukemia (66%) and had frequent hyperlactatemia (64%) on ICU admission. ICU non-survivors demonstrated higher lactate levels and hyperlactatemia frequency at various time points (0, 6, and 12 h) than survivors. Lactate clearance and liver function tests did not differ significantly between the two groups. Invasive mechanical ventilation [OR (95% confidence interval-CI): 20.4 (2.4–79.8), p  
ISSN:0939-5555
1432-0584
1432-0584
DOI:10.1007/s00277-024-05977-5