Neuroprotective effects of brown rice consumption in an iron-induced parkinsonism in Drosophila

Iron (Fe) accumulation and resultant oxidative stress play a significant role in the neuronal death observed in Parkinson's disease (PD). Brown rice (BR) possesses antioxidant properties able to reduce cellular oxidative damage. Thus, we hypothesized that BR may ameliorate Fe-induced parkinsoni...

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Bibliographic Details
Published in:Nutritional neuroscience 2024-09, p.1-11
Main Authors: Uthman, Yaaqub Abiodun, Ibrahim, Kasimu Ghandi, Abubakar, Murtala Bello, Sulaiman, Ismail, Imam, Mustapha Umar
Format: Article
Language:English
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Summary:Iron (Fe) accumulation and resultant oxidative stress play a significant role in the neuronal death observed in Parkinson's disease (PD). Brown rice (BR) possesses antioxidant properties able to reduce cellular oxidative damage. Thus, we hypothesized that BR may ameliorate Fe-induced parkinsonism due to oxidative stress. Two - to three-day-old male flies were concurrently exposed to Fe (ferrous sulphate, 1 mM) and interventions, divided into eight groups: control; Fe; BR; white rice (WR); L-dopa (1 mM); Fe (1 mM) + BR; Fe (1 mM) + WR; and Fe (1 mM) + L-dopa (1 mM). The flies were exposed for 15 days to their respective diets, and their behavior, relevant biomarkers, and the expression of related genes were evaluated. Chronic exposure to Fe caused cognitive and locomotor deficits by increasing Fe levels  = 0.027) in flies' heads, as well as heightened aggression and grooming episodes (  
ISSN:1028-415X
1476-8305
1476-8305
DOI:10.1080/1028415X.2024.2399988