HIV incidence among non-migrating persons following a household migration event in Uganda

• Published in: International journal of epidemiology 2024-08, Vol.53 (5)
• Main Authors: Young, Ruth, Ssekasanvu, Joseph, Kagaayi, Joseph, Ssekubugu, Robert, Kigozi, Godfrey, Reynolds, Steven J, Wawer, Maria J, Nonyane, Bareng Aletta Sanny, Nantume, Betty, Quinn, Thomas C, Tobian, Aaron A R, Santelli, John, Chang, Larry W, Kennedy, Caitlin E, Paina, Ligia, Anglewicz, Philip A, Serwadda, David, Nalugoda, Fred, Grabowski, Mary Kate
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Cohort Studies; Family Characteristics; Female; HIV Infections - epidemiology; Humans; Incidence; Male; Middle Aged; Risk Factors; Transients and Migrants - statistics & numerical data; Uganda - epidemiology; Young Adult
• ISSN: 1464-3685; 1464-3685
• DOI: 10.1093/ije/dyae118

Abstract Background The impact of migration on HIV risk among non-migrating household members is poorly understood. We measured HIV incidence among non-migrants living in households with and without migrants in Uganda. Methods We used four survey rounds of data collected from July 2011 to May 2018 from non-migrant participants aged 15–49 years in the Rakai Community Cohort Study. Non-migrants were individuals with no-migration between surveys or at the prior survey. Household migration was defined as ≥1 household member migrating into or out of the house from another community between surveys (∼18 months). Incident HIV was defined as testing HIV seropositive following a negative result. Incidence rate ratios (IRRs) were estimated using Poisson regression with generalized estimating equations. Analyses were stratified by gender, migration into or out of the household and the relationship between non-migrants and migrants (e.g. spouse, child). Results About 11 318 non-migrants (5674 women) were followed for 37 320 person-years. Twenty-eight percent (6059/21 370) of non-migrant person-visits had recent migration into or out of the household, and 240 HIV incident cases were identified. Overall, non-migrants in migrant households were not at greater risk of acquiring HIV than non-migrants in households without any migration. However, men were significantly more likely to acquire HIV if their spouse had recently migrated in [adjusted IRR: 2.12; 95% confidence interval (CI): 1.05–4.27] or out (adjusted IRR: 4.01; 95% CI, 2.16–7.44) compared with men with no spousal migration. Conclusions HIV incidence is higher among non-migrant men with migrant spouses. Targeted HIV testing and prevention interventions like pre-exposure prophylaxis could be considered for men with migrant spouses.