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Molecular evolution and genotype shift of Porcine circoviruses type 2 in Vietnam
Porcine Circovirus Type 2 (PCV2), a significant pathogen in the global swine industry, causes Porcine Circovirus Associated Diseases (PCVAD), contributing to substantial economic losses. This study investigates the genetic diversity and evolutionary dynamics of PCV2 in Vietnam from 2007 to 2023. We...
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| Published in: | Veterinary research communications 2024-12, Vol.48 (6), p.4097-4103 |
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| container_end_page | 4103 |
| container_issue | 6 |
| container_start_page | 4097 |
| container_title | Veterinary research communications |
| container_volume | 48 |
| creator | Lai, Danh Cong Le, Dung Khanh Thi Nguyen, Trung Huu Van Thach, Manh Hue, Vo Thi Van Le, Phan Ngo, Tram Ngoc Thi Nguyen, Nam Minh Do, Duy Tien |
| description | Porcine Circovirus Type 2 (PCV2), a significant pathogen in the global swine industry, causes Porcine Circovirus Associated Diseases (PCVAD), contributing to substantial economic losses. This study investigates the genetic diversity and evolutionary dynamics of PCV2 in Vietnam from 2007 to 2023. We sequenced and analyzed 47 PCV2 genomes isolated from swine farms across Vietnam between 2022 and 2023, revealing predominant circulation of PCV2d (80.85%) followed by PCV2b (19.15%). Phylogenetic analysis identified PCV2 genotypes PCV2a, PCV2b, PCV2d, PCV2g, and PCV2h circulating in Vietnam, with PCV2d emerging as the most prevalent genotype. Comparison with historical data highlighted genotype shifts from PCV2b to PCV2d in 2014. Interestingly, PCV2h genotype was mainly observed between 2008 and 2012 but have not been detected since 2014. Regional analysis indicated varied PCV2 epidemiological patterns between northern and southern Vietnam. Amino acid substitutions within the capsid protein were identified, predominantly in antigenic regions critical for immune recognition. Positive selection analysis identified multiple sites under evolutionary pressure, indicating ongoing adaptation of Vietnamese PCV2 strains. These findings enhance understanding of PCV2 dynamics in Vietnam and underscore the importance of continuous surveillance and adaptive management strategies in controlling PCV2-associated diseases in swine populations. |
| doi_str_mv | 10.1007/s11259-024-10521-x |
| format | article |
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This study investigates the genetic diversity and evolutionary dynamics of PCV2 in Vietnam from 2007 to 2023. We sequenced and analyzed 47 PCV2 genomes isolated from swine farms across Vietnam between 2022 and 2023, revealing predominant circulation of PCV2d (80.85%) followed by PCV2b (19.15%). Phylogenetic analysis identified PCV2 genotypes PCV2a, PCV2b, PCV2d, PCV2g, and PCV2h circulating in Vietnam, with PCV2d emerging as the most prevalent genotype. Comparison with historical data highlighted genotype shifts from PCV2b to PCV2d in 2014. Interestingly, PCV2h genotype was mainly observed between 2008 and 2012 but have not been detected since 2014. Regional analysis indicated varied PCV2 epidemiological patterns between northern and southern Vietnam. Amino acid substitutions within the capsid protein were identified, predominantly in antigenic regions critical for immune recognition. Positive selection analysis identified multiple sites under evolutionary pressure, indicating ongoing adaptation of Vietnamese PCV2 strains. These findings enhance understanding of PCV2 dynamics in Vietnam and underscore the importance of continuous surveillance and adaptive management strategies in controlling PCV2-associated diseases in swine populations.</description><identifier>ISSN: 0165-7380</identifier><identifier>ISSN: 1573-7446</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-024-10521-x</identifier><identifier>PMID: 39243305</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>adaptive management ; Amino acids ; Animals ; Biomedical and Life Sciences ; Brief Report ; Capsid protein ; Circoviridae Infections - epidemiology ; Circoviridae Infections - veterinary ; Circoviridae Infections - virology ; Circovirus - classification ; Circovirus - genetics ; coat proteins ; Epidemiology ; Evolution, Molecular ; Genetic diversity ; Genetic Variation ; genome ; Genome, Viral ; Genotype ; Genotype & phenotype ; Genotypes ; Life Sciences ; Molecular evolution ; monitoring ; pathogens ; Phylogeny ; Porcine circovirus ; Porcine circovirus-2 ; pork industry ; Positive selection ; selection pressure ; Swine ; Swine Diseases - epidemiology ; Swine Diseases - virology ; Veterinary Medicine/Veterinary Science ; Vietnam ; Vietnam - epidemiology ; Zoology</subject><ispartof>Veterinary research communications, 2024-12, Vol.48 (6), p.4097-4103</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. 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Positive selection analysis identified multiple sites under evolutionary pressure, indicating ongoing adaptation of Vietnamese PCV2 strains. These findings enhance understanding of PCV2 dynamics in Vietnam and underscore the importance of continuous surveillance and adaptive management strategies in controlling PCV2-associated diseases in swine populations.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>39243305</pmid><doi>10.1007/s11259-024-10521-x</doi><tpages>7</tpages></addata></record> |
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| subjects | adaptive management Amino acids Animals Biomedical and Life Sciences Brief Report Capsid protein Circoviridae Infections - epidemiology Circoviridae Infections - veterinary Circoviridae Infections - virology Circovirus - classification Circovirus - genetics coat proteins Epidemiology Evolution, Molecular Genetic diversity Genetic Variation genome Genome, Viral Genotype Genotype & phenotype Genotypes Life Sciences Molecular evolution monitoring pathogens Phylogeny Porcine circovirus Porcine circovirus-2 pork industry Positive selection selection pressure Swine Swine Diseases - epidemiology Swine Diseases - virology Veterinary Medicine/Veterinary Science Vietnam Vietnam - epidemiology Zoology |
| title | Molecular evolution and genotype shift of Porcine circoviruses type 2 in Vietnam |
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