Potential Predictor of Epigenetic Age Acceleration in Men: 2D:4D Finger Pattern

ABSTRACT Objectives Second to fourth digit ratio is widely known indicator of prenatal sex hormones proportion. Higher prenatal androgenization results in longer fourth finger and lower 2D:4D index. The aim of this study was to determine whether the 2D:4D digit ratio is associated with DNA methylati...

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Published in:American journal of human biology 2024-11, Vol.36 (11), p.e24151-n/a
Main Authors: Pruszkowska‐Przybylska, Paulina, Noroozi, Rezvan, Rudnicka, Joanna, Pisarek, Aleksandra, Wronka, Iwona, Kobus, Magdalena, Wysocka, Bożena, Ossowski, Andrzej, Spólnicka, Magdalena, Wiktorska, Joanna, Iljin, Aleksandra, Pośpiech, Ewelina, Branicki, Wojciech, Sitek, Aneta
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aging
Aging - genetics
Aging - physiology
Algorithms
Clocks
digit ratio
DNA Methylation
DNA microarrays
DNAmAge
Epigenesis, Genetic
epigenetic age
Epigenetics
Estrogens
Female
Females
Finger
Fingers
Fingers - anatomy & histology
Genomic analysis
Hormones
Humans
Male
Males
Middle Aged
Pattern analysis
Prenatal experience
prenatal sex hormones proportion
prenatal testosterone
Sex hormones
Sex ratio
Technology assessment
Two dimensional analysis
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Summary:ABSTRACT Objectives Second to fourth digit ratio is widely known indicator of prenatal sex hormones proportion. Higher prenatal androgenization results in longer fourth finger and lower 2D:4D index. The aim of this study was to determine whether the 2D:4D digit ratio is associated with DNA methylation (DNAm) age dependently on sex. Material and Methods The study included 182 adults (106 females and 76 males) with a mean age of 51.5 ± 13 years. The investigation consisted of three main parts: a survey, anthropometric dimensions measurements (fingers length) and methylome analysis using collected blood samples. Genome‐wide methylation was analyzed using EPIC microarray technology. Epigenetic age and epigenetic age acceleration were calculated using several widely applied algorithms. Results Males with the female left hand pattern had more accelerated epigenetic age than those with the male pattern as calculated with PhenoAge and DNAmTL clocks. Conclusions Finger female pattern 2D:4D above or equal to 1 in males is associated with epigenetic age acceleration, indicating that prenatal exposure to estrogens in males may be related to aging process in the later ontogenesis.
ISSN:1042-0533
1520-6300
1520-6300
DOI:10.1002/ajhb.24151