Therapeutic innovations for geographic atrophy: A promising horizon

This mini review spotlights the most promising treatments for geographic atrophy, the advanced form of age-related macular degeneration, often resulting in severe and irreversible vision loss. The pathophysiology is complex, and various therapeutic strategies, including anticomplement therapies, gen...

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Bibliographic Details
Published in:Current opinion in pharmacology 2024-10, Vol.78, p.102484, Article 102484
Main Authors: de Oliveira Figueiredo, Eva C., Bucolo, Claudio, Eandi, Chiara M.
Format: Article
Language:English
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Summary:This mini review spotlights the most promising treatments for geographic atrophy, the advanced form of age-related macular degeneration, often resulting in severe and irreversible vision loss. The pathophysiology is complex, and various therapeutic strategies, including anticomplement therapies, gene therapies, cell-based interventions, and artificial intelligence–driven diagnostics are discussed. Anticomplement therapies (antifactors C3 and C5) showed promise in reducing the inflammatory response and the progression of the atrophy. Gene therapies, targeting specific genetic mutations, are under development to correct underlying defects and potentially reverse disease progression. Cell-based therapies are gaining momentum, with early studies indicating encouraging results in the replacement of damaged retinal pigment epithelium cells.
ISSN:1471-4892
1471-4973
1471-4973
DOI:10.1016/j.coph.2024.102484