The Tiny Big Difference: Nanotechnology in Photoprotective Innovations – A Systematic Review

UV radiation causes long- and short-term skin damage, such as erythema and skin cancer. Therefore, the use of sunscreens is extremely important. However, concerns about UV filter safety have prompted exploration into alternative solutions, with nanotechnology emerging as a promising avenue. This sys...

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Bibliographic Details
Published in:AAPS PharmSciTech 2024-09, Vol.25 (7), p.212, Article 212
Main Authors: Nascimento Júnior, José Adão Carvalho, Santos, Anamaria Mendonça, Oliveira, Ana Maria Santos, Santos, Alcimary Bispo, de Souza Araújo, Adriano Antunes, Aragón, Diana Marcela, Frank, Luiza Abrahão, Serafini, Mairim Russo
Format: Article
Language:English
Subjects:
Animals
Antioxidants - administration & dosage
Antioxidants - chemistry
Antioxidants - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Carriers - chemistry
Humans
Lipids - chemistry
Nanoparticles - chemistry
Nanotechnology - methods
Pharmacology/Toxicology
Pharmacy
Polymers - chemistry
Review Article
Skin - drug effects
Skin - metabolism
Skin Absorption - drug effects
Sun Protection Factor
Sunscreening Agents - administration & dosage
Sunscreening Agents - chemistry
Ultraviolet Rays - adverse effects
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Summary:UV radiation causes long- and short-term skin damage, such as erythema and skin cancer. Therefore, the use of sunscreens is extremely important. However, concerns about UV filter safety have prompted exploration into alternative solutions, with nanotechnology emerging as a promising avenue. This systematic review identified 23 experimental studies utilizing nanocarriers to encapsulate sunscreens with the aim of enhancing their efficacy and safety. Polymeric and lipid nanoparticles are frequently employed to encapsulate both organic and inorganic UV filters along with natural antioxidants. Nanocarriers have demonstrated benefits including reduced active ingredient usage, increased sun protection factor, and mitigated photoinstability. Notably, they also decreased the skin absorption of UV filters. In summary, nanocarriers represent a viable strategy for improving sunscreen formulations, offering enhanced physicochemical properties and bolstered photoprotective effects, thereby addressing concerns regarding UV filter safety and efficacy in cosmetic applications. Graphical Abstract
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-024-02925-4