Direct C-H amidation of 1,3-azoles: light-mediated, photosensitiser-free vs. thermal

We have developed one thermal and one light-mediated method for direct Minisci-type C-H amidation of 1,3-azoles, which are applicable to thiazoles, benzothiazoles, benzimidazoles, and for the first time, imidazoles. The new visible light-mediated approach can be rendered photosensitiser/photocatalys...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-09, Vol.60 (77), p.10752-10755
Main Authors: Mooney, David T, McKee, Heather, Batch, Tabea S, Drane, Samuel, Moore, Peter R, Lee, Ai-Lan
Format: Article
Language:English
Subjects:
Heterocyclic compounds
Imidazole
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Summary:We have developed one thermal and one light-mediated method for direct Minisci-type C-H amidation of 1,3-azoles, which are applicable to thiazoles, benzothiazoles, benzimidazoles, and for the first time, imidazoles. The new visible light-mediated approach can be rendered photosensitiser/photocatalyst-free and likely proceeds an electron donor-acceptor (EDA) complex, the first direct Minisci-type amidation to do so.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc02742f