Performance of the MiniMed 780G system on mitigating menstrual cycle‐dependent glycaemic variability

• Published in: Diabetes, obesity & metabolism obesity & metabolism, 2024-11, Vol.26 (11), p.4916-4923
• Main Authors: Elhenawy, Yasmine Ibrahim, Abdel Kader, Mohamed S., Thabet, Rasha A.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; advanced hybrid closed‐loop; Algorithms; Blood Glucose - analysis; Blood Glucose - metabolism; Blood Glucose Self-Monitoring - methods; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Female; Follicular Phase - physiology; Glucose monitoring; Glycemic Control - methods; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - therapeutic use; Insulin; Insulin - administration & dosage; Insulin Infusion Systems; Luteal Phase - drug effects; Menstrual cycle; Menstrual Cycle - physiology; Menstruation; Pilot Projects; time in range; type 1 diabetes; Young Adult
• ISSN: 1462-8902; 1463-1326; 1463-1326
• DOI: 10.1111/dom.15891

Aim To map the glycaemic variabilities and insulin requirements across different phases of the menstrual cycle and assess the efficacy and performance of the MiniMed 780G system on mitigating glycaemic variabilities during phases of the menstrual cycle. Materials and Methods A pilot study recruiting 15 adolescent and young adult females with type 1 diabetes was conducted. Only females with regular spontaneous menstruation were enrolled in the current study. Phases of each menstrual cycle were determined as either follicular phase or luteal phase. The study analysed continuous glucose monitoring metrics during two study periods: the open loop period (OLP) and the advanced hybrid closed‐loop (AHCL) period; each period lasted 3 consecutive months. Results During the OLP, the mean time in range (TIR) significantly decreased during the luteal phase compared with the follicular phase (65.13% ± 3.07% vs. 70.73% ± 2.05%) (P