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Major reduction in occurrence of anti‐c and anti‐E in pregnancy after more than 10 years of preventive matched transfusion with most benefit for c‐matching
Summary Extension with cE‐matching of the transfusion policy for women under 45 years to prevent alloimmunization and hemolytic disease of the foetus and newborn (HDFN) was evaluated. After implementation of cEK‐matching, anti‐c occurrence decreased from 46.8 to 30.4 per 100 000 pregnancies (RR 0.65...
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| Published in: | British journal of haematology 2024-10, Vol.205 (4), p.1599-1604 |
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| container_end_page | 1604 |
| container_issue | 4 |
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| container_title | British journal of haematology |
| container_volume | 205 |
| creator | Luken, Jessie S. Folman, Claudia C. Meekers, Johan H. Lukens, Michael V. Schoot, C. Ellen Haas, Masja |
| description | Summary
Extension with cE‐matching of the transfusion policy for women under 45 years to prevent alloimmunization and hemolytic disease of the foetus and newborn (HDFN) was evaluated. After implementation of cEK‐matching, anti‐c occurrence decreased from 46.8 to 30.4 per 100 000 pregnancies (RR 0.65, 95% CI 0.54–0.79), while anti‐E occurrence decreased from 122.1 to 89.9 per 100 000 pregnancies (RR 0.74, 95% CI 0.66–0.84). The c‐negative women showed a higher anti‐E occurrence before cEK‐matching and a more pronounced decline with the new policy. This indicates that cEK‐matched transfusion effectively reduces alloimmunization, and that a cK‐matched approach could prevent most transfusion‐related alloimmunization and HDFN. |
| doi_str_mv | 10.1111/bjh.19740 |
| format | article |
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Extension with cE‐matching of the transfusion policy for women under 45 years to prevent alloimmunization and hemolytic disease of the foetus and newborn (HDFN) was evaluated. After implementation of cEK‐matching, anti‐c occurrence decreased from 46.8 to 30.4 per 100 000 pregnancies (RR 0.65, 95% CI 0.54–0.79), while anti‐E occurrence decreased from 122.1 to 89.9 per 100 000 pregnancies (RR 0.74, 95% CI 0.66–0.84). The c‐negative women showed a higher anti‐E occurrence before cEK‐matching and a more pronounced decline with the new policy. This indicates that cEK‐matched transfusion effectively reduces alloimmunization, and that a cK‐matched approach could prevent most transfusion‐related alloimmunization and HDFN.</description><identifier>ISSN: 0007-1048</identifier><identifier>ISSN: 1365-2141</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.19740</identifier><identifier>PMID: 39252551</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Blood Group Incompatibility - prevention & control ; Blood Grouping and Crossmatching - methods ; Blood Transfusion - methods ; Erythroblastosis, Fetal - prevention & control ; Female ; hemolytic disease of the fetus and newborn ; Humans ; immunohaematology ; Infant, Newborn ; Isoantibodies - blood ; Isoantibodies - immunology ; Middle Aged ; Pregnancy ; red cell antigens ; Rh-Hr Blood-Group System - immunology ; transfusion ; Transfusion Reaction - prevention & control</subject><ispartof>British journal of haematology, 2024-10, Vol.205 (4), p.1599-1604</ispartof><rights>2024 British Society for Haematology and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2150-2a72d91e68b212bfc210e36953f80ca80dfb76c00e2a0719f057700dc4f11ae53</cites><orcidid>0000-0003-1480-7879 ; 0000-0002-7044-0525 ; 0000-0001-7300-6794 ; 0000-0003-1346-4202 ; 0000-0002-8065-3540</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39252551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luken, Jessie S.</creatorcontrib><creatorcontrib>Folman, Claudia C.</creatorcontrib><creatorcontrib>Meekers, Johan H.</creatorcontrib><creatorcontrib>Lukens, Michael V.</creatorcontrib><creatorcontrib>Schoot, C. Ellen</creatorcontrib><creatorcontrib>Haas, Masja</creatorcontrib><title>Major reduction in occurrence of anti‐c and anti‐E in pregnancy after more than 10 years of preventive matched transfusion with most benefit for c‐matching</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Extension with cE‐matching of the transfusion policy for women under 45 years to prevent alloimmunization and hemolytic disease of the foetus and newborn (HDFN) was evaluated. After implementation of cEK‐matching, anti‐c occurrence decreased from 46.8 to 30.4 per 100 000 pregnancies (RR 0.65, 95% CI 0.54–0.79), while anti‐E occurrence decreased from 122.1 to 89.9 per 100 000 pregnancies (RR 0.74, 95% CI 0.66–0.84). The c‐negative women showed a higher anti‐E occurrence before cEK‐matching and a more pronounced decline with the new policy. This indicates that cEK‐matched transfusion effectively reduces alloimmunization, and that a cK‐matched approach could prevent most transfusion‐related alloimmunization and HDFN.</description><subject>Adult</subject><subject>Blood Group Incompatibility - prevention & control</subject><subject>Blood Grouping and Crossmatching - methods</subject><subject>Blood Transfusion - methods</subject><subject>Erythroblastosis, Fetal - prevention & control</subject><subject>Female</subject><subject>hemolytic disease of the fetus and newborn</subject><subject>Humans</subject><subject>immunohaematology</subject><subject>Infant, Newborn</subject><subject>Isoantibodies - blood</subject><subject>Isoantibodies - immunology</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>red cell antigens</subject><subject>Rh-Hr Blood-Group System - immunology</subject><subject>transfusion</subject><subject>Transfusion Reaction - prevention & control</subject><issn>0007-1048</issn><issn>1365-2141</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3DAURi1UBFNgwQsgL9tFZu514mSybBGFVqBuyjpynGvGo4kz2A5odmy76zvwZjxJPQx0V2_8o_Oda-lj7BRhimnN2uViinVVwB6bYF7KTGCBH9gEAKoMoZgfso8hLAEwB4kH7DCvhRRS4oQ936jl4LmnbtTRDo5bxwetR-_JaeKD4cpF-_L0R6dD93652GJrT3dOOb3hykTyvB888bhQjiO8PP3ekPJhK0jcA6XcA_FeRb2gjkevXDBj2A58tHGRsiHylhwZG7lJH9Jpyitt3d0x2zdqFejkbT9it98ufp1fZdc_L7-ff7nOtEAJmVCV6Gqkct4KFK1Jr0B5WcvczEGrOXSmrUoNQEJBhbUBWVUAnS4MoiKZH7FPO-_aD_cjhdj0NmharZSjYQxNjiCKFJRlQj_vUO2HEDyZZu1tr_ymQWi2nTSpk-a1k8SevWnHtqfuH_leQgJmO-DRrmjzf1Pz9cfVTvkXPtKbeg</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Luken, Jessie S.</creator><creator>Folman, Claudia C.</creator><creator>Meekers, Johan H.</creator><creator>Lukens, Michael V.</creator><creator>Schoot, C. Ellen</creator><creator>Haas, Masja</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1480-7879</orcidid><orcidid>https://orcid.org/0000-0002-7044-0525</orcidid><orcidid>https://orcid.org/0000-0001-7300-6794</orcidid><orcidid>https://orcid.org/0000-0003-1346-4202</orcidid><orcidid>https://orcid.org/0000-0002-8065-3540</orcidid></search><sort><creationdate>202410</creationdate><title>Major reduction in occurrence of anti‐c and anti‐E in pregnancy after more than 10 years of preventive matched transfusion with most benefit for c‐matching</title><author>Luken, Jessie S. ; Folman, Claudia C. ; Meekers, Johan H. ; Lukens, Michael V. ; Schoot, C. Ellen ; Haas, Masja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2150-2a72d91e68b212bfc210e36953f80ca80dfb76c00e2a0719f057700dc4f11ae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Blood Group Incompatibility - prevention & control</topic><topic>Blood Grouping and Crossmatching - methods</topic><topic>Blood Transfusion - methods</topic><topic>Erythroblastosis, Fetal - prevention & control</topic><topic>Female</topic><topic>hemolytic disease of the fetus and newborn</topic><topic>Humans</topic><topic>immunohaematology</topic><topic>Infant, Newborn</topic><topic>Isoantibodies - blood</topic><topic>Isoantibodies - immunology</topic><topic>Middle Aged</topic><topic>Pregnancy</topic><topic>red cell antigens</topic><topic>Rh-Hr Blood-Group System - immunology</topic><topic>transfusion</topic><topic>Transfusion Reaction - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luken, Jessie S.</creatorcontrib><creatorcontrib>Folman, Claudia C.</creatorcontrib><creatorcontrib>Meekers, Johan H.</creatorcontrib><creatorcontrib>Lukens, Michael V.</creatorcontrib><creatorcontrib>Schoot, C. Ellen</creatorcontrib><creatorcontrib>Haas, Masja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luken, Jessie S.</au><au>Folman, Claudia C.</au><au>Meekers, Johan H.</au><au>Lukens, Michael V.</au><au>Schoot, C. Ellen</au><au>Haas, Masja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major reduction in occurrence of anti‐c and anti‐E in pregnancy after more than 10 years of preventive matched transfusion with most benefit for c‐matching</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2024-10</date><risdate>2024</risdate><volume>205</volume><issue>4</issue><spage>1599</spage><epage>1604</epage><pages>1599-1604</pages><issn>0007-1048</issn><issn>1365-2141</issn><eissn>1365-2141</eissn><abstract>Summary
Extension with cE‐matching of the transfusion policy for women under 45 years to prevent alloimmunization and hemolytic disease of the foetus and newborn (HDFN) was evaluated. After implementation of cEK‐matching, anti‐c occurrence decreased from 46.8 to 30.4 per 100 000 pregnancies (RR 0.65, 95% CI 0.54–0.79), while anti‐E occurrence decreased from 122.1 to 89.9 per 100 000 pregnancies (RR 0.74, 95% CI 0.66–0.84). The c‐negative women showed a higher anti‐E occurrence before cEK‐matching and a more pronounced decline with the new policy. This indicates that cEK‐matched transfusion effectively reduces alloimmunization, and that a cK‐matched approach could prevent most transfusion‐related alloimmunization and HDFN.</abstract><cop>England</cop><pmid>39252551</pmid><doi>10.1111/bjh.19740</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1480-7879</orcidid><orcidid>https://orcid.org/0000-0002-7044-0525</orcidid><orcidid>https://orcid.org/0000-0001-7300-6794</orcidid><orcidid>https://orcid.org/0000-0003-1346-4202</orcidid><orcidid>https://orcid.org/0000-0002-8065-3540</orcidid></addata></record> |
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| issn | 0007-1048 1365-2141 1365-2141 |
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| source | Wiley |
| subjects | Adult Blood Group Incompatibility - prevention & control Blood Grouping and Crossmatching - methods Blood Transfusion - methods Erythroblastosis, Fetal - prevention & control Female hemolytic disease of the fetus and newborn Humans immunohaematology Infant, Newborn Isoantibodies - blood Isoantibodies - immunology Middle Aged Pregnancy red cell antigens Rh-Hr Blood-Group System - immunology transfusion Transfusion Reaction - prevention & control |
| title | Major reduction in occurrence of anti‐c and anti‐E in pregnancy after more than 10 years of preventive matched transfusion with most benefit for c‐matching |
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