Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors

ALI/ARDS can be a pulmonary manifestation of a systemic inflammatory response or a result of overexpression of the body’s normal inflammatory response involving various effector cells, cytokines, and inflammatory mediators, which regulate the body’s immune response through different signalling pathw...

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Bibliographic Details
Published in:Lung 2024-10, Vol.202 (5), p.513-522
Main Authors: Zhu, Xi, Meng, Leyuan, Xu, Liqin, Hua, Yun, Feng, Jian
Format: Article
Language:English
Subjects:
Acetylation
Acute Lung Injury - drug therapy
Acute Lung Injury - metabolism
Animals
Biological effects
Cell cycle
Cell differentiation
Cell migration
Cell proliferation
Chemical synthesis
Deacetylation
DNA biosynthesis
DNA damage
Effector cells
Forkhead protein
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
Gene expression
Humans
Immune response
Inflammation
Inflammatory response
Medicine
Medicine & Public Health
Molecular Targeted Therapy
Phosphorylation
Pneumology/Respiratory System
Protein biosynthesis
Protein synthesis
Protein turnover
Respiratory Distress Syndrome - drug therapy
Respiratory Distress Syndrome - metabolism
Review
Signal Transduction
Therapeutic targets
Transcription factors
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Summary:ALI/ARDS can be a pulmonary manifestation of a systemic inflammatory response or a result of overexpression of the body’s normal inflammatory response involving various effector cells, cytokines, and inflammatory mediators, which regulate the body’s immune response through different signalling pathways. Forkhead box transcription factors are evolutionarily conserved transcription factors that play a crucial role in various cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Transcription factors control protein synthesis by regulating gene transcription levels, resulting in diverse biological outcomes. The Fox family plays a role in activating or inhibiting the expression of various molecules related to ALI/ARDS through phosphorylation, acetylation/deacetylation, and control of multiple signalling pathways. An in-depth analysis of the integrated Fox family’s role in ALI/ARDS can aid in the development of potential diagnostic and therapeutic targets for the condition.
ISSN:0341-2040
1432-1750
1432-1750
DOI:10.1007/s00408-024-00740-z