The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation

Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking. In this study, we sought to i...

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Bibliographic Details
Published in:Journal of sexual medicine 2024-10, Vol.21 (11), p.1030-1036
Main Authors: Chen, Zhimin, Zheng, Zhenming, Zhang, Xiansheng
Format: Article
Language:English
Subjects:
Adult
Evoked Potentials, Somatosensory - physiology
Galvanic Skin Response - physiology
Humans
Male
Penis - innervation
Premature Ejaculation - diagnosis
Premature Ejaculation - physiopathology
Sensory Thresholds - physiology
Young Adult
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Summary:Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking. In this study, we sought to investigate the use of electrophysiologic parameters to assist in the classification of PE, thereby guiding subsequent treatment. From July 2023 to April 2024, 187 study participants were enrolled. For each participant, the biological sensory threshold (BST), penile sympathetic skin response (PSSR), and dorsal nerve somatosensory evoked potential (DNSEP) were recorded. The differences in the PSSR latencies (PL) and DNSEP latencies (DL), the PSSR amplitudes (PA) and DNSEP amplitudes (DA), and the BST were compared among the LPE, APE, SPE, NPE, and healthy control (HC) groups. The participants were divided into the LPE (46 cases), APE (53 cases), SPE (20 cases), NPE (33 cases), and HC (35 cases) groups. The results showed shorter latencies of the PSSR (PL) and DNSEP (DL), larger amplitudes of the PSSR (PA) and DNSEP (DL), and smaller BST in the LPE group than in the NPE, SPE, APE, and HC groups (P 
ISSN:1743-6095
1743-6109
1743-6109
DOI:10.1093/jsxmed/qdae109