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The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation
Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking. In this study, we sought to i...
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| Published in: | Journal of sexual medicine 2024-10, Vol.21 (11), p.1030-1036 |
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| creator | Chen, Zhimin Zheng, Zhenming Zhang, Xiansheng |
| description | Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking.
In this study, we sought to investigate the use of electrophysiologic parameters to assist in the classification of PE, thereby guiding subsequent treatment.
From July 2023 to April 2024, 187 study participants were enrolled. For each participant, the biological sensory threshold (BST), penile sympathetic skin response (PSSR), and dorsal nerve somatosensory evoked potential (DNSEP) were recorded.
The differences in the PSSR latencies (PL) and DNSEP latencies (DL), the PSSR amplitudes (PA) and DNSEP amplitudes (DA), and the BST were compared among the LPE, APE, SPE, NPE, and healthy control (HC) groups.
The participants were divided into the LPE (46 cases), APE (53 cases), SPE (20 cases), NPE (33 cases), and HC (35 cases) groups. The results showed shorter latencies of the PSSR (PL) and DNSEP (DL), larger amplitudes of the PSSR (PA) and DNSEP (DL), and smaller BST in the LPE group than in the NPE, SPE, APE, and HC groups (P |
| doi_str_mv | 10.1093/jsxmed/qdae109 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3102881594</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3102881594</sourcerecordid><originalsourceid>FETCH-LOGICAL-c180t-5aa3935c923881fd5697892e053938563cd303e5f51b72bf099b6d0239017ace3</originalsourceid><addsrcrecordid>eNo1UD1PwzAUtBCIQmFlRB5Z0tpxncQjqviSKrGUlchxXlpHTpzaTkX_Pa7avuXdO92dng6hJ0pmlAg2b_1fB_V8V0uI9xW6o_mCJVnE1xdMBJ-ge-9bQlic9BZNmEh5sSjIHfpdbwHvpRkB2waDARWcHbYHr62xG62kwQF80P0G6x6HKJZ1O_Yq6D3gWstNb732R-_goJNhdIChlWo0MmjbP6CbRhoPj-c9RT_vb-vlZ7L6_vhavq4SRQsSEi4lE4wrkbKioE3NM5EXIgXCI13wjKmaEQa84bTK06ohQlRZTVImCM2lAjZFL6fcwdndGB8uO-0VGCN7sKMvGSVpTOZiEaWzk1Q5672Dphyc7qQ7lJSUx07LU6fludNoeD5nj9WRv8gvJbJ_sZp1oQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3102881594</pqid></control><display><type>article</type><title>The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation</title><source>Oxford Journals Online</source><creator>Chen, Zhimin ; Zheng, Zhenming ; Zhang, Xiansheng</creator><creatorcontrib>Chen, Zhimin ; Zheng, Zhenming ; Zhang, Xiansheng</creatorcontrib><description><![CDATA[Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking.
In this study, we sought to investigate the use of electrophysiologic parameters to assist in the classification of PE, thereby guiding subsequent treatment.
From July 2023 to April 2024, 187 study participants were enrolled. For each participant, the biological sensory threshold (BST), penile sympathetic skin response (PSSR), and dorsal nerve somatosensory evoked potential (DNSEP) were recorded.
The differences in the PSSR latencies (PL) and DNSEP latencies (DL), the PSSR amplitudes (PA) and DNSEP amplitudes (DA), and the BST were compared among the LPE, APE, SPE, NPE, and healthy control (HC) groups.
The participants were divided into the LPE (46 cases), APE (53 cases), SPE (20 cases), NPE (33 cases), and HC (35 cases) groups. The results showed shorter latencies of the PSSR (PL) and DNSEP (DL), larger amplitudes of the PSSR (PA) and DNSEP (DL), and smaller BST in the LPE group than in the NPE, SPE, APE, and HC groups (P < .05). In addition, the larger PA and shorter PL in the APE group than in the NPE and HC groups (P < .05). However, the electrophysiological parameters were not significantly different among the NPE, SPE, and HC groups (P > .05). In addition, PL <1262.0 milliseconds and DL <41.85 milliseconds were strong predictors of LPE, 1262.0 milliseconds < PL <1430.0 milliseconds was a predictor of APE, and PL >1430.0 milliseconds suggested possible SPE or NPE.
Analysis of the electrophysiological parameters of PE may be helpful for classification and treatment.
No previous study, to our knowledge, has analyzed the electrophysiological parameters of the four types of PE. The main limitation is the small sample size.
APE is characterized by increased sympathetic excitability, whereas LPE is characterized by increased penile sensitivity and increased sympathetic excitability. However, penile sensitivity and sympathetic excitability in SPE and NPE patients may not differ significantly from normal.]]></description><identifier>ISSN: 1743-6095</identifier><identifier>ISSN: 1743-6109</identifier><identifier>EISSN: 1743-6109</identifier><identifier>DOI: 10.1093/jsxmed/qdae109</identifier><identifier>PMID: 39258480</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Adult ; Evoked Potentials, Somatosensory - physiology ; Galvanic Skin Response - physiology ; Humans ; Male ; Penis - innervation ; Premature Ejaculation - diagnosis ; Premature Ejaculation - physiopathology ; Sensory Thresholds - physiology ; Young Adult</subject><ispartof>Journal of sexual medicine, 2024-10, Vol.21 (11), p.1030-1036</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Sexual Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c180t-5aa3935c923881fd5697892e053938563cd303e5f51b72bf099b6d0239017ace3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39258480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zhimin</creatorcontrib><creatorcontrib>Zheng, Zhenming</creatorcontrib><creatorcontrib>Zhang, Xiansheng</creatorcontrib><title>The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation</title><title>Journal of sexual medicine</title><addtitle>J Sex Med</addtitle><description><![CDATA[Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking.
In this study, we sought to investigate the use of electrophysiologic parameters to assist in the classification of PE, thereby guiding subsequent treatment.
From July 2023 to April 2024, 187 study participants were enrolled. For each participant, the biological sensory threshold (BST), penile sympathetic skin response (PSSR), and dorsal nerve somatosensory evoked potential (DNSEP) were recorded.
The differences in the PSSR latencies (PL) and DNSEP latencies (DL), the PSSR amplitudes (PA) and DNSEP amplitudes (DA), and the BST were compared among the LPE, APE, SPE, NPE, and healthy control (HC) groups.
The participants were divided into the LPE (46 cases), APE (53 cases), SPE (20 cases), NPE (33 cases), and HC (35 cases) groups. The results showed shorter latencies of the PSSR (PL) and DNSEP (DL), larger amplitudes of the PSSR (PA) and DNSEP (DL), and smaller BST in the LPE group than in the NPE, SPE, APE, and HC groups (P < .05). In addition, the larger PA and shorter PL in the APE group than in the NPE and HC groups (P < .05). However, the electrophysiological parameters were not significantly different among the NPE, SPE, and HC groups (P > .05). In addition, PL <1262.0 milliseconds and DL <41.85 milliseconds were strong predictors of LPE, 1262.0 milliseconds < PL <1430.0 milliseconds was a predictor of APE, and PL >1430.0 milliseconds suggested possible SPE or NPE.
Analysis of the electrophysiological parameters of PE may be helpful for classification and treatment.
No previous study, to our knowledge, has analyzed the electrophysiological parameters of the four types of PE. The main limitation is the small sample size.
APE is characterized by increased sympathetic excitability, whereas LPE is characterized by increased penile sensitivity and increased sympathetic excitability. However, penile sensitivity and sympathetic excitability in SPE and NPE patients may not differ significantly from normal.]]></description><subject>Adult</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>Galvanic Skin Response - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Penis - innervation</subject><subject>Premature Ejaculation - diagnosis</subject><subject>Premature Ejaculation - physiopathology</subject><subject>Sensory Thresholds - physiology</subject><subject>Young Adult</subject><issn>1743-6095</issn><issn>1743-6109</issn><issn>1743-6109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo1UD1PwzAUtBCIQmFlRB5Z0tpxncQjqviSKrGUlchxXlpHTpzaTkX_Pa7avuXdO92dng6hJ0pmlAg2b_1fB_V8V0uI9xW6o_mCJVnE1xdMBJ-ge-9bQlic9BZNmEh5sSjIHfpdbwHvpRkB2waDARWcHbYHr62xG62kwQF80P0G6x6HKJZ1O_Yq6D3gWstNb732R-_goJNhdIChlWo0MmjbP6CbRhoPj-c9RT_vb-vlZ7L6_vhavq4SRQsSEi4lE4wrkbKioE3NM5EXIgXCI13wjKmaEQa84bTK06ohQlRZTVImCM2lAjZFL6fcwdndGB8uO-0VGCN7sKMvGSVpTOZiEaWzk1Q5672Dphyc7qQ7lJSUx07LU6fludNoeD5nj9WRv8gvJbJ_sZp1oQ</recordid><startdate>20241031</startdate><enddate>20241031</enddate><creator>Chen, Zhimin</creator><creator>Zheng, Zhenming</creator><creator>Zhang, Xiansheng</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241031</creationdate><title>The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation</title><author>Chen, Zhimin ; Zheng, Zhenming ; Zhang, Xiansheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c180t-5aa3935c923881fd5697892e053938563cd303e5f51b72bf099b6d0239017ace3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Evoked Potentials, Somatosensory - physiology</topic><topic>Galvanic Skin Response - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Penis - innervation</topic><topic>Premature Ejaculation - diagnosis</topic><topic>Premature Ejaculation - physiopathology</topic><topic>Sensory Thresholds - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhimin</creatorcontrib><creatorcontrib>Zheng, Zhenming</creatorcontrib><creatorcontrib>Zhang, Xiansheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of sexual medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhimin</au><au>Zheng, Zhenming</au><au>Zhang, Xiansheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation</atitle><jtitle>Journal of sexual medicine</jtitle><addtitle>J Sex Med</addtitle><date>2024-10-31</date><risdate>2024</risdate><volume>21</volume><issue>11</issue><spage>1030</spage><epage>1036</epage><pages>1030-1036</pages><issn>1743-6095</issn><issn>1743-6109</issn><eissn>1743-6109</eissn><abstract><![CDATA[Although the four-class system of classifying premature ejaculation (PE), including lifelong PE (LPE), acquired PE (APE), natural variable PE (NPE), and subjective PE (SPE), has existed for many years, objective classification standards in clinical practice are lacking.
In this study, we sought to investigate the use of electrophysiologic parameters to assist in the classification of PE, thereby guiding subsequent treatment.
From July 2023 to April 2024, 187 study participants were enrolled. For each participant, the biological sensory threshold (BST), penile sympathetic skin response (PSSR), and dorsal nerve somatosensory evoked potential (DNSEP) were recorded.
The differences in the PSSR latencies (PL) and DNSEP latencies (DL), the PSSR amplitudes (PA) and DNSEP amplitudes (DA), and the BST were compared among the LPE, APE, SPE, NPE, and healthy control (HC) groups.
The participants were divided into the LPE (46 cases), APE (53 cases), SPE (20 cases), NPE (33 cases), and HC (35 cases) groups. The results showed shorter latencies of the PSSR (PL) and DNSEP (DL), larger amplitudes of the PSSR (PA) and DNSEP (DL), and smaller BST in the LPE group than in the NPE, SPE, APE, and HC groups (P < .05). In addition, the larger PA and shorter PL in the APE group than in the NPE and HC groups (P < .05). However, the electrophysiological parameters were not significantly different among the NPE, SPE, and HC groups (P > .05). In addition, PL <1262.0 milliseconds and DL <41.85 milliseconds were strong predictors of LPE, 1262.0 milliseconds < PL <1430.0 milliseconds was a predictor of APE, and PL >1430.0 milliseconds suggested possible SPE or NPE.
Analysis of the electrophysiological parameters of PE may be helpful for classification and treatment.
No previous study, to our knowledge, has analyzed the electrophysiological parameters of the four types of PE. The main limitation is the small sample size.
APE is characterized by increased sympathetic excitability, whereas LPE is characterized by increased penile sensitivity and increased sympathetic excitability. However, penile sensitivity and sympathetic excitability in SPE and NPE patients may not differ significantly from normal.]]></abstract><cop>Netherlands</cop><pmid>39258480</pmid><doi>10.1093/jsxmed/qdae109</doi><tpages>7</tpages></addata></record> |
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| source | Oxford Journals Online |
| subjects | Adult Evoked Potentials, Somatosensory - physiology Galvanic Skin Response - physiology Humans Male Penis - innervation Premature Ejaculation - diagnosis Premature Ejaculation - physiopathology Sensory Thresholds - physiology Young Adult |
| title | The value of electrophysiological testing in the adjunctive diagnosis of premature ejaculation |
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