Menopausal stage transitions and their associations with overall and individual sleep quality in middle-aged Korean women

• Published in: Journal of affective disorders 2025-01, Vol.368, p.82-89
• Main Authors: Jang, Yoonyoung, Chang, Yoosoo, Park, Junhee, Kim, Chanmin, Jeon, Sang Won, Kang, Jeonggyu, Kwon, Ria, Lim, Ga-young, Kim, Kye-Hyun, Kim, Hoon, Hong, Yun Soo, Park, Jihwan, Zhao, Di, Cho, Juhee, Guallar, Eliseo, Park, Hyun-Young, Ryu, Seungho
• Format: Article
• Language: English
• Subjects: Adult; Female; Humans; Longitudinal Studies; Menopausal transition; Menopause - physiology; Middle Aged; Middle-aged Korean women; Overweight; Overweight - epidemiology; Pittsburgh Sleep Quality Index (PSQI); Republic of Korea; Sleep disorder; Sleep Quality; Sleep Wake Disorders - epidemiology
• ISSN: 0165-0327; 1573-2517; 1573-2517
• DOI: 10.1016/j.jad.2024.09.050

Understanding the association between the menopausal transition and declining sleep quality can guide optimal timing for preventive interventions in transitioning women. However, studies lack representation of Asian women and sufficient data on the progression of menopausal stages and sleep quality changes over time in this population. This study included 3305 women in the pre-menopause stage at baseline. The sleep quality and its components were assessed using the Pittsburgh Sleep Quality Index (PSQI). Menopausal stages were classified as pre-menopause, early transition, late transition, and post-menopause according to the Stages of Reproductive Aging Workshop+10 (STRAW+10) criteria. We estimated the longitudinal association between menopausal stage changes over time and the PSQI score, and examined the effect of being overweight. The trends in the PSQI scores and its components according to the menopausal stage changes over time showed that with the exception of sleep duration and habitual sleep efficiency, an overall decline was noted in sleep health during late transition and post-menopause compared to pre-menopause. These associations were independent of time-variant annual chronological aging, which was not significantly associated with sleep deterioration. Additionally, although the associations between menopausal stages and sleep quality did not significantly differ by adiposity level, the overweight group exhibited worse PSQI scores and components than did the non-overweight group. Sleep quality and menopausal stage were assessed using self-reported questionnaires without objective measures. Our study underscores the importance of screening for sleep quality deterioration and implementing appropriate measures for women experiencing menopausal transition. •Deterioration in PSQI scores and components was observed across menopausal transition according to the STRAW+10 criteria.•These associations were significant, independent of time-variant annual chronological aging.•The associations between menopausal stages and sleep quality did not significantly differ by adiposity level.