Tumor budding is associated with poor prognosis and clinicopathologic factors in esophageal carcinoma: A meta-analysis

Tumor budding is associated with the prognosis of several solid cancers, but further evidence is needed to identify its relation with esophageal cancer. Our study aims to assess the relationship between tumor budding and overall survival, disease-free survival, and clinicopathologic variables in EC....

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Published in:European journal of surgical oncology 2024-12, Vol.50 (12), p.108668, Article 108668
Main Authors: Regmi, Sagar Mani, Regmi, Parbatraj, Paudyal, Aliza, Upadhyay, Diksha, Lamichhane, Sadikchya, Dahal, Alok, Thatal, Sunil, Tiwari, Apil
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Disease-Free Survival
Esophageal cancer
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Humans
Lymphatic Metastasis
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
Survival Rate
Tumor budding
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Summary:Tumor budding is associated with the prognosis of several solid cancers, but further evidence is needed to identify its relation with esophageal cancer. Our study aims to assess the relationship between tumor budding and overall survival, disease-free survival, and clinicopathologic variables in EC. Multiple electronic databases were searched and 20 relevant studies containing 3370 patients were identified. The fixed effects and a random-effects model were used to perform a meta-analysis. Tumor budding was associated with poor overall survival in EC in both univariate analyses (HR:2.63; 95 % CI 2.06–3.38; p 
ISSN:0748-7983
1532-2157
1532-2157
DOI:10.1016/j.ejso.2024.108668