A new nomogram for the evaluation of detrusor underactivity and bladder outlet obstruction in nonneurogenic female patients with lower urinary tract symptoms who undergo urodynamic studies

Introduction Micturition physiology differs in men and women. However, the results in standard urodynamic studies in women with lower urinary tract symptoms (LUTS) were extrapolated from studies in men. Nowadays, the only validated nomogram for females is Solomon–Greenwell's. However, it only e...

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Published in:Neurourology and urodynamics 2024-11, Vol.43 (8), p.2076-2083
Main Authors: Barco‐Castillo, Catalina, Sotelo Perilla, Melida, Rangel Amaya, Jaime, Castaño, Juan Carlos
Format: Article
Language:English
Subjects:
bladder outlet obstruction
detrusor underactivity
Females
flow‐pressure studies
Kidney transplantation
Neurological diseases
Nomograms
Physiology
Regression analysis
Urinary tract
Urination
urodynamic studies
Urogenital system
Women
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Summary:Introduction Micturition physiology differs in men and women. However, the results in standard urodynamic studies in women with lower urinary tract symptoms (LUTS) were extrapolated from studies in men. Nowadays, the only validated nomogram for females is Solomon–Greenwell's. However, it only evaluated bladder outlet obstruction (BOO) without considering detrusor underactivity (DU). This study aims to create a nomogram that includes an evaluation of DU and BOO in nonneurogenic women and validate it against videourodynamic studies along with other nomograms. Materials and Methods For the first analysis (creation cohort), we included 183 women with LUTS who underwent videourodynamic study between 2022 and 2023. Exclusion criteria were females with neurologic diseases, renal transplantation, and trouble performing the flow‐pressure study. Baseline characteristics of the patients, urodynamic parameters, and classifications on different nomograms and indexes were evaluated. A logistic regression found Qmax and PdetQmax as predictors for DU and BOO. The Barco–Castillo nomogram was created by clustering analysis and adjusted by the results of the logistic regression. A second (test) cohort was evaluated from 2023 to 2024, including 142 patients for the validation of the nomogram. A p 
ISSN:0733-2467
1520-6777
1520-6777
DOI:10.1002/nau.25553