Protein kinase C epsilon contributes to chronic mechanoreflex sensitization in rats with heart failure

We investigated second-messenger signalling components linked to the stimulation of G protein-coupled receptors (e.g. thromboxane A and bradykinin B2 receptors) on the sensory endings of thin fibre muscle afferents in the chronic mechanoreflex sensitization in rats with myocardial infarction-induced...

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Bibliographic Details
Published in:The Journal of physiology 2024-09
Main Authors: Butenas, Alec L E, Parr, Shannon K, Flax, Joseph S, Carroll, Raimi J, Baranczuk, Ashley M, Ade, Carl J, Hageman, K Sue, Musch, Timothy I, Copp, Steven W
Format: Article
Language:English
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Summary:We investigated second-messenger signalling components linked to the stimulation of G protein-coupled receptors (e.g. thromboxane A and bradykinin B2 receptors) on the sensory endings of thin fibre muscle afferents in the chronic mechanoreflex sensitization in rats with myocardial infarction-induced heart failure with reduced ejection fraction (HF-rEF). We hypothesized that injection of either the inositol 1,4,5-trisphosphate (IP ) receptor antagonist xestospongin C (5 µg) or the PKCε translocation inhibitor PKCe141 (45 µg) into the arterial supply of the hindlimb would reduce the increase in renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) evoked during 30 s of 1 Hz dynamic hindlimb muscle stretch in decerebrate, unanaesthetized HF-rEF rats but not sham-operated controls (SHAM). Ejection fraction was significantly reduced in HF-rEF (45 (19)%) compared to SHAM (80 (9)%; P 
ISSN:0022-3751
1469-7793
1469-7793
DOI:10.1113/JP287020