Comparative analysis of classic network vs. nanogel junction network in konjac glucomannan/kappa carrageenan hybrid hydrogels

• Published in: International journal of biological macromolecules 2024-11, Vol.279 (Pt 4), p.135244, Article 135244
• Main Authors: Peleg-Evron, Or, Wirzeberger, Dana, Davidovich-Pinhas, Maya, Cometa, Stefania, De Giglio, Elvira, Bianco-Peled, Havazelet
• Format: Article
• Language: English
• Subjects: Dissolution; Hydrogels; Kappa carrageenan; Konjac glucomannan; Nanogels
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.135244

The three-dimensional network architecture of hydrogels significantly influences their mechanical and physical properties; therefore, understanding them is essential for designing optimized hydrogel-based biomaterials. This study presents a comparative analysis of two hybrid hydrogels composed of konjac glucomannan (KGM) and kappa carrageenan (KCAR) with the same stiffness (5.2–5.7 kPa and 1.6–1.7 kPa) thus similar cross-linking density but different network architectures: a classic network formed by extended polysaccharide interactions and a nanogel junction network where nanoscale cross-linked KCAR (KCAR-NGs) links KGM chains. The mechanical behavior, dissolution, and diffusion characteristics were examined, revealing that the classic network demonstrates superior tensile resistance, elongation, and solvent-induced swelling resistance, leading to slower dissolution rates and higher viscosity. Conversely, the nanogel junction network offers higher permeability for small molecules and faster dissolution, suggesting a more open network structure. These findings highlight the nanogel-based hydrogels' advantages for biomedical applications requiring stability, permeability, and rapid dissolution without high temperatures or chelating agents. This study underscores the potential of nanogel junction networks to balance hydrogel stiffness and permeability, advancing the design of hydrogel-based biomaterials. [Display omitted] •Comparison of classic and nanogel junction networks composed of konjac glucomannan/kappa carrageenan hybrid hydrogels.•The nanogel-based network offers strong permeability while maintaining stiffness, an advantage in designing biomaterials.•The classic network has superior tensile resistance, elongation, and slower dissolution.•Both networks exhibit self-healing and shear-thinning properties.