Mesenchymal Tumor Management: Integrating Surgical and Non-Surgical Strategies in Different Clinical Scenarios

Mesenchymal tumors originate from mesenchymal cells and can be either benign or malignant, such as bone, soft tissue, and visceral sarcomas. Surgery is a cornerstone treatment in the management of mesenchymal tumors, often requiring complex procedures performed in high-volume referral centers. Howev...

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Bibliographic Details
Published in:Cancers 2024-08, Vol.16 (17), p.2965
Main Authors: Samà, Laura, Rodda, Giorgia Amy, Ruspi, Laura, Sicoli, Federico, D'Amato, Vittoria, Renne, Salvatore Lorenzo, Laffi, Alice, Baldaccini, Davide, Clerici, Elena, Navarria, Pierina, Scorsetti, Marta, Bertuzzi, Alexia Francesca, Quagliuolo, Vittorio Lorenzo, Cananzi, Ferdinando Carlo Maria
Format: Article
Language:English
Subjects:
Abdomen
Bone surgery
Bone tumors
Cancer therapies
Clinical trials
COVID-19
Laparoscopy
Liposarcoma
Malignancy
Mesenchyme
Patients
Radiation therapy
Sarcoma
Surgery
Toxicity
Tumors
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Summary:Mesenchymal tumors originate from mesenchymal cells and can be either benign or malignant, such as bone, soft tissue, and visceral sarcomas. Surgery is a cornerstone treatment in the management of mesenchymal tumors, often requiring complex procedures performed in high-volume referral centers. However, the COVID-19 pandemic has highlighted this need for alternative non-surgical approaches due to limited access to surgical resources. This review explores the role of non-surgical treatments in different clinical scenarios: for improving surgical outcomes, as a bridge to surgery, as better alternatives to surgery, and for non-curative treatment when surgery is not feasible. We discuss the effectiveness of active surveillance, cryoablation, high-intensity focused ultrasound, and other ablative techniques in managing these tumors. Additionally, we examine the use of tyrosine kinase inhibitors in gastrointestinal stromal tumors and hypofractionated radiotherapy in soft tissue sarcomas. The Sarculator tool is highlighted for its role in stratifying high-risk sarcoma patients and personalizing treatment plans. While surgery remains the mainstay of treatment, integrating advanced non-surgical strategies can enhance therapeutic possibilities and patient care, especially in specific clinical settings with limitations. A multidisciplinary approach in referral centers is vital to determine the optimal treatment course for each patient.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16172965