Lactiplantibacillus plantarum 06CC2 Enhanced the Expression of Intestinal Uric Acid Excretion Transporter in Mice

ATP-binding cassette transporter subfamily G member 2 (ABCG2) is responsible for the excretion of foreign substances, such as uric acid (UA) and indoxyl sulfate (IS), from the body. Given the importance of increased ABCG2 expression in UA excretion, we investigated the enhancement of intestinal ABCG...

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Published in:Nutrients 2024-09, Vol.16 (17), p.3042
Main Authors: Nei, Shunsuke, Matsusaki, Tatsuya, Kawakubo, Hibiki, Ogawa, Kenjirou, Nishiyama, Kazuo, Tsend-Ayush, Chuluunbat, Nakano, Tomoki, Takeshita, Masahiko, Shinyama, Takuo, Yamasaki, Masao
Format: Article
Language:English
Subjects:
ABC transporters
Animals
ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics
ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism
Bacteria
Dairy products
Diet
excretion
Feces
Feces - chemistry
Feces - microbiology
Intestinal Mucosa - metabolism
Intestine, Small - metabolism
Intestines - microbiology
Kidneys
Laboratories
Lactobacillaceae - metabolism
Lactobacillus plantarum - metabolism
Male
Metabolism
Metabolites
Mice
Polyclonal antibodies
Potassium
Probiotics
Proteins
Rheumatism
small intestine
subfamily
sulfates
Uric acid
Uric Acid - metabolism
Uric Acid - urine
Urine
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Summary:ATP-binding cassette transporter subfamily G member 2 (ABCG2) is responsible for the excretion of foreign substances, such as uric acid (UA) and indoxyl sulfate (IS), from the body. Given the importance of increased ABCG2 expression in UA excretion, we investigated the enhancement of intestinal ABCG2 expression using 06CC2 (LP06CC2). Mice were reared on a potassium oxonate-induced high-purine model at doses of 0.02% or 0.1% LP06CC2 for three weeks. Results showed that LP06CC2 feeding resulted in increased ABCG2 expression in the small intestine. The expression level of large intestinal ABCG2 also showed a tendency to increase, suggesting upregulation of the intestinal excretion transporter ABCG2 by LP06CC2. Overall, LP06CC2 treatment increased fecal UA excretion and showed a trend towards increased fecal excretion of IS, suggesting that LP06CC2 treatment enhanced the expression of intestinal ABCG2, thereby promoting the excretion of UA and other substances from the intestinal tract.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16173042