Phages to the rescue: in situ editing of the gut microbiota

The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriophages to efficiently deliver gene editors without propagation of the genetic cargo, efficiently introd...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2024-10, Vol.32 (10), p.934-935
Main Authors: Kamm, Charlotte, Beisel, Chase L.
Format: Article
Language:English
Subjects:
base editing
cosmid
CRISPR
in situ editing
microbiome editing
phage engineering
phagemid
Citations: Items that this one cites
Online Access:Get full text
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Summary:The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriophages to efficiently deliver gene editors without propagation of the genetic cargo, efficiently introducing edits to bacteria residing in the mouse gut. The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriophages to efficiently deliver gene editors without propagation of the genetic cargo, efficiently introducing edits to bacteria residing in the mouse gut.
ISSN:0966-842X
1878-4380
1878-4380
DOI:10.1016/j.tim.2024.09.001