Diagnostic Accuracy of Dermatoscopy Versus Microbiological Culture and Polymerase Chain Reaction in the Diagnosis of Onychomycosis: A Cross‐Sectional Study

ABSTRACT Background Several clinical signs in dermatoscopy are very characteristic of onychomycosis and can be a quick complement for the diagnosis of onychomycosis. Objectives The aim of this study was to evaluate the diagnostic accuracy of dermatoscopy compared to microbiological culture and polym...

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Published in:Mycoses 2024-09, Vol.67 (9), p.e13799-n/a
Main Authors: Navarro‐Pérez, David, Tardáguila‐García, Aroa, García‐Oreja, Sara, León‐Herce, Diego, Álvaro‐Afonso, Francisco Javier, Lázaro‐Martínez, José Luis
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Cross-Sectional Studies
dermatoscopy
Dermoscopy - methods
Detritus
Diagnosis
Female
Fungi - genetics
Fungi - isolation & purification
Humans
Male
microbiological culture
Microbiological Techniques - methods
Middle Aged
Onychomycosis
Onychomycosis - diagnosis
Onychomycosis - microbiology
Patients
Polymerase chain reaction
Polymerase Chain Reaction - methods
polymerase chain reaction and nail pathology
Predictive Value of Tests
Sensitivity and Specificity
Young Adult
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Summary:ABSTRACT Background Several clinical signs in dermatoscopy are very characteristic of onychomycosis and can be a quick complement for the diagnosis of onychomycosis. Objectives The aim of this study was to evaluate the diagnostic accuracy of dermatoscopy compared to microbiological culture and polymerase chain reaction (PCR), as well as the clinical signs associated with onychomycosis. Methods The clinical signs of 125 patients were assessed cross‐sectionally using dermatoscopy, and a positive or negative result was assigned. A sample was then taken for PCR and microbiological culture. Results Of the 125 patients, 69.6% (87/125) had positive results when both laboratory tests were combined. When they were not combined, the prevalence was lower at 48% (60/125) with PCR and at 43.2% (54/125) with culture. Furthermore, 76.8% (96/125) were classified as positive with dermatoscopy with a sensitivity of 1, a specificity of 0.76, positive predictive value of 0.91 and negative predictive value of 1 (with 95% confidence intervals). Of the 96 dermatoscopy‐positive samples, 36 were negative with PCR (p 
ISSN:0933-7407
1439-0507
1439-0507
DOI:10.1111/myc.13799