Association of late eating with colorectal adenomas: a cross-sectional study

• Published in: European journal of nutrition 2024-12, Vol.63 (8), p.3187-3193
• Main Authors: Adnan, Darbaz, Khoshaba, Edena R., Abel-Reheem, Mostafa, Trinh, Jonathan Q., Cao, Yin, Bishehsari, Faraz
• Format: Article
• Language: English
• Subjects: Adenoma; Adult; Aged; Carcinogenesis; Chemistry; Chemistry and Materials Science; Circadian rhythms; Colon; Colonoscopy - methods; Colonoscopy - statistics & numerical data; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Colorectal Neoplasms - epidemiology; Cross-Sectional Studies; Diet - methods; Diet - statistics & numerical data; Dietary intake; Feeding Behavior; Female; Food consumption; Food intake; histology; Humans; lifestyle; Male; Middle Aged; Nutrition; Original Contribution; Polyps; Risk Factors; sleep; Sleep - physiology; Sleep and wakefulness; Surveys and Questionnaires; Time Factors; Tumors
• ISSN: 1436-6207; 1436-6215; 1436-6215
• DOI: 10.1007/s00394-024-03499-4

Purpose Colorectal cancer (CRC) is linked to lifestyle exposures. However, changes in the CRC rates among younger populations remain poorly understood and suggest the existence of yet unidentified factor(s) that may contribute to colon carcinogenesis. Here, we investigated the potential role of time of eating in the risk of pre-cancerous colonic neoplasms (tubular adenoma: TA). Methods We enrolled 663 participants undergoing screening colonoscopies. Data on food timing, dietary intake, sleep/wake patterns, and chronotype were collected through structured questionnaires. Late eating was defined as the consumption of food or snack within a 3-hour window of sleep onset for at least four days a week. Pathology reports confirmed the histology of colonic polyps, and adenomas were further classified into risk categories. Results A total of 644 patients met criteria for our study. There were 270 (42.2%) participants classified as late eaters. Compared to non-late eaters, the odds of TA were higher in late eaters (OR = 1.46, 95% CI = 1.05–2.03, p  = 0.023), an association which was strengthened after adjusting for multiple confounders (OR 1.98, 95% CI 1.19–3.28, p  = 0.008). Late eating remained an independent risk factor for high-risk as well as multiple TAs. Conclusion This study proposes late eating as a risk factor for colon tubular adenomas and underscores the potential role of less studied forms of circadian disruption imposed by time of eating in the development of colon neoplastic formation.