Association Between Cardiorespiratory Fitness and Trend of Age-Related Rise in Arterial Stiffness in Individuals With and Without Hypertension or Diabetes

This study aimed to investigate whether higher cardiorespiratory fitness (CRF) can modify the trend of age-related rise in arterial stiffness in individuals with and without hypertension (HTN) or diabetes. The study included 4,935 participants who underwent maximal cardiopulmonary exercise testing w...

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Published in:American journal of hypertension 2024-12, Vol.38 (1), p.46
Main Authors: Jae, Sae Young, Lee, Kyung Hyun, Kim, Hyun Jeong, Kunutsor, Setor K, Pierce, Gary L, Hui, Stanley Sai-Chuen, Kang, Mira
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aging - physiology
Ankle Brachial Index
Cardiorespiratory Fitness
Cross-Sectional Studies
Diabetes Mellitus - epidemiology
Diabetes Mellitus - physiopathology
Exercise Test
Female
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - physiopathology
Male
Middle Aged
Pulse Wave Analysis
Risk Factors
Vascular Stiffness
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Summary:This study aimed to investigate whether higher cardiorespiratory fitness (CRF) can modify the trend of age-related rise in arterial stiffness in individuals with and without hypertension (HTN) or diabetes. The study included 4,935 participants who underwent maximal cardiopulmonary exercise testing with respiratory gas analysis in a health screening program. CRF was directly measured using peak oxygen uptake during the cardiopulmonary exercise test, while arterial stiffness was evaluated using brachial-ankle pulse wave velocity (baPWV). Participants with high CRF levels had significantly lower baPWV compared with those with low CRF levels, regardless of HTN or diabetes status (P 
ISSN:0895-7061
1941-7225
1941-7225
DOI:10.1093/ajh/hpae124