Investigating the influence of estrous cycle-dependent hormonal changes on neurogenesis in adult mice

[Display omitted] •The serum estrogen and FSH increased in Proestrous stage.•Progesterone and prolactin hormones were increased in the Diaestrus stage.•The expression levels of BDNF, NGF, and CNTF genes increased in the hippocampal tissue of Proestrous and Diaestrus stages.•The number of GFAP+cells...

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Published in:Steroids 2024-12, Vol.212, p.109513, Article 109513
Main Authors: Mirzaeian, Leila, Bahrehbar, Khadijeh, Emamdoust, Mandana, Amiri, Masoumeh, Azari, Maryam, Taghi Ghorbanian, Mohammad
Format: Article
Language:English
Subjects:
Animals
Brain-Derived Neurotrophic Factor - metabolism
Estrous Cycle
Female
Gonadal Steroid Hormones - metabolism
Hippocampus
Hippocampus - cytology
Hippocampus - metabolism
Mice
Neurogenesis
Sex hormones
Subventricular zone
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Summary:[Display omitted] •The serum estrogen and FSH increased in Proestrous stage.•Progesterone and prolactin hormones were increased in the Diaestrus stage.•The expression levels of BDNF, NGF, and CNTF genes increased in the hippocampal tissue of Proestrous and Diaestrus stages.•The number of GFAP+cells in SVZ of the Proestrous and Diestrous stages had an increase. Neurogenesis is the process of generating new neurons from neural stem cells (NSCs) in the adult brain. Sex hormones play an essential role in the development of the brain. The aim of this study was to evaluate the neurogenic changes in the brain at different phases of the estrous cycle in adult mice. Female NMRI mice were divided into four groups: 1- Estrous, 2- Proestrous, 3- Metestrous, and 4- Diestrous. Different stages of the estrous cycle were determined by staining of vaginal smears. The level of estrogen, progesterone, prolactin, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) hormones was evaluated by the enzyme-linked immunosorbent assay (ELISA) method. The expression of brain-derived neurotrophic factor) BDNF), nerve growth factor (NGF), ciliary neurotrophic factor(CNTF)) genes in hippocampal and the expression of glial fibrillary acidic protein (GFAP) in subventricular zone (SVZ) tissue were evaluated. The serum estrogen and FSH increased significantly in Proestrous group (p 
ISSN:0039-128X
1878-5867
1878-5867
DOI:10.1016/j.steroids.2024.109513