Recent applications of three-dimensional bioprinting in drug discovery and development

• Published in: Advanced drug delivery reviews 2024-11, Vol.214, p.115456, Article 115456
• Main Authors: Yang, Kaixing, Wang, Lingxin, Vijayavenkataraman, Sanjairaj, Yuan, Yunong, Tan, Edwin C.K., Kang, Lifeng
• Format: Article
• Language: English
• Subjects: 3D bioprinting; Additive manufacturing; Animals; Bioprinting - methods; Clinical trials; Drug Development - methods; Drug Discovery - methods; High-throughput screening; Humans; In vitro drug testing; Lead identification; Preclinical studies; Printing, Three-Dimensional; Target selection
• ISSN: 0169-409X; 1872-8294; 1872-8294
• DOI: 10.1016/j.addr.2024.115456

[Display omitted] The ability of three-dimensional (3D) bioprinting to fabricate biomimetic organ and disease models has been recognised to be promising for drug discovery and development as 3D bioprinted models can better mimic human physiology compared to two-dimensional (2D) cultures and animal models. This is useful for target selection where disease models can be studied to understand disease pathophysiology and identify disease-linked compounds. Lead identification and preclinical studies also benefit from 3D bioprinting as 3D bioprinted models can be utilised in high-throughput screening (HTS) systems and to produce efficacy and safety data that closely resembles clinical observations. Although no published applications of 3D bioprinting in clinical trials were found, there are two clinical trials planning to evaluate the predictive ability of 3D bioprinted models by comparing human and model responses to the same chemotherapy. Overall, this review provides a comprehensive summary of the latest applications of 3D bioprinting in drug discovery and development.