Adherence to a healthful plant-based diet and risk of mortality among individuals with chronic kidney disease: A prospective cohort study

• Published in: Clinical nutrition (Edinburgh, Scotland) Scotland), 2024-10, Vol.43 (10), p.2448-2457
• Main Authors: Thompson, Alysha S., Gaggl, Martina, Bondonno, Nicola P., Jennings, Amy, O'Neill, Joshua K., Hill, Claire, Karavasiloglou, Nena, Rohrmann, Sabine, Cassidy, Aedín, Kühn, Tilman
• Format: Article
• Language: English
• Subjects: Chronic kidney disease; Management of CKD; Mortality; Plant-based diet index
• ISSN: 0261-5614; 1532-1983; 1532-1983
• DOI: 10.1016/j.clnu.2024.09.021

Plant-rich dietary patterns may protect against negative health outcomes among individuals with chronic kidney disease (CKD), although aspects of plant-based diet quality have not been studied. This study aimed to examine associations between healthful and unhealthful plant-based dietary patterns with risk of all-cause mortality among CKD patients for the first time. This prospective analysis included 4807 UK Biobank participants with CKD at baseline. We examined associations of adherence to both the healthful plant-based diet index (hPDI) and unhealthful plant-based diet index (uPDI), calculated from repeated 24-h dietary assessments, with risk of all-cause mortality using multivariable Cox proportional hazard regression models. Over a 10-year follow-up, 675 deaths were recorded. Participants with the highest hPDI scores showed a 34% lower risk of mortality [HRQ4vsQ1 (95% CI): 0.66 (0.52–0.83), ptrend