Profiles of disease progression and predictors of mortality in Colombian patients with amyotrophic lateral sclerosis: a comprehensive longitudinal study

• Published in: Amyotrophic lateral sclerosis and frontotemporal degeneration 2024-09, p.1-8
• Main Authors: Ortiz-Corredor, Fernando, Correa-Arrieta, Cristian, Forero Diaz, John Jairo, Castellar-Leones, Sandra, Gil-Salcedo, Andrés
• Format: Article
• Language: English
• ISSN: 2167-8421; 2167-9223; 2167-9223
• DOI: 10.1080/21678421.2024.2405587

: This study aimed to assess the prognostic value of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) in predicting mortality and characterizing disease progression patterns in ALS patients in Colombia. : We conducted a retrospective longitudinal analysis of 537 ALS patients from the Roosevelt Institute Rehabilitation Service between October 2008 and October 2022. The study excluded nine patients due to incomplete data, resulting in 528 individuals in the analysis. ALS diagnoses were confirmed using the revised El Escorial and Gold Coast criteria. Disease progression was assessed using the ALSFRS-R, and mortality data were sourced from follow-up calls and a national database. Statistical analysis included Cox proportional hazards models to identify mortality predictors and Growth Mixture Modeling (GMM) to explore ALS progression trajectories. : The majority of the cohort (63.8%) deceased within the 84-month follow-up period. Survival analysis revealed that each point increase in the ALSFRS-R rate was associated with a 2.22-fold (95% CI =1.99-2.48,