Efficacy of Probiotics in Overweight and Obesity Control: An Umbrella Review and Subgroup Meta-Analysis

Numerous primary and secondary studies have consistently demonstrated that probiotics, including lactobacillus and Bifidobacterium, possess a potential anti-obesity effect. However, it is worth noting that some studies have yielded contrasting results. Considering this, our study aims to present a c...

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Bibliographic Details
Published in:Probiotics and antimicrobial proteins 2024-12, Vol.16 (6), p.2316-2328
Main Authors: Sadeghi, A., Daroudi, R., Davari, M., Gharib-Naseri, Z., Jafarzadeh, J., Tajvar, M.
Format: Article
Language:English
Subjects:
Applied Microbiology
Biomedical and Life Sciences
Body fat
Body Mass Index
Body weight
Chemistry/Food Science
Humans
Life Sciences
Meta-analysis
Microbiology
Nutrition
Obesity
Obesity - diet therapy
Overweight
Probiotics
Probiotics - administration & dosage
Probiotics - therapeutic use
Protein Science
Review
Reviews
Statistical analysis
Weight control
Citations: Items that this one cites
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Summary:Numerous primary and secondary studies have consistently demonstrated that probiotics, including lactobacillus and Bifidobacterium, possess a potential anti-obesity effect. However, it is worth noting that some studies have yielded contrasting results. Considering this, our study aims to present a comprehensive overview of published systematic reviews and meta-analyses, focusing on the efficacy and safety of probiotics in managing obesity. To achieve this objective, we conducted an umbrella review following the PRISMA protocol and Cochrane guidelines. We searched databases such as Embase, PubMed, Cochrane Library, and Google Scholar for relevant systematic reviews and meta-analyses published in English, without imposing any date restrictions. Our inclusion criteria encompassed studies evaluating the anti-obesity impact of probiotics, with a specific focus on changes in body mass index (BMI), fat mass percentage (FMP), body weight (BW), and body fat mass (BFM). These studies were meticulously reviewed by two independent reviewers. Our analysis included five systematic reviews and 18 meta-analyses that met the predefined inclusion and exclusion criteria. The meta-analyses revealed statistically significant reductions in the following parameters: BMI, a decrease of 0.30 kg/m 2 ( p  
ISSN:1867-1306
1867-1314
1867-1314
DOI:10.1007/s12602-024-10363-8