Extensive Pulmonary AL Amyloidosis Mimicking Miliary Tuberculosis: The Diagnostic Utility of 99m Tc-PYP Scintigraphy

Amyloidosis is a misfolded protein deposition disorder within the extracellular matrix, leading to dysfunction in the affected organ. Primary amyloidosis manifests as AL and ATTR subtypes, wherein AL is associated with plasma cell dyscrasias. Herein we present a case of a patient who underwent inves...

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Bibliographic Details
Published in:Clinical nuclear medicine 2024-11, Vol.49 (11), p.e608
Main Authors: Denizmen, Dilara, Isik, Emine Goknur, Vuralli Bakkaloglu, Dogu, Buyukkaya, Fikret, Sanli, Yasemin
Format: Article
Language:English
Subjects:
Aged
Amyloidosis - diagnostic imaging
Diagnosis, Differential
Female
Humans
Immunoglobulin Light-chain Amyloidosis - diagnostic imaging
Lung Diseases - diagnostic imaging
Male
Middle Aged
Radionuclide Imaging
Technetium Tc 99m Pyrophosphate
Tuberculosis, Miliary - diagnostic imaging
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Summary:Amyloidosis is a misfolded protein deposition disorder within the extracellular matrix, leading to dysfunction in the affected organ. Primary amyloidosis manifests as AL and ATTR subtypes, wherein AL is associated with plasma cell dyscrasias. Herein we present a case of a patient who underwent investigation due to the presence of bilateral reticulonodular lung infiltrates, suggestive of miliary tuberculosis. 99m Tc-PYP scan revealed widespread radiotracer uptake in the lungs leading to diagnosis of AL amyloidosis.
ISSN:1536-0229
1536-0229
DOI:10.1097/RLU.0000000000005442