Outcomes of Charcot-Marie-Tooth Disease Cavovarus Surgical Reconstruction

Background: Charcot-Marie-Tooth (CMT) disease is a progressive inherited neurologic disorder causing muscle weakness and lower extremity deformity. The goal of foot and ankle surgical treatment is to create a stable, plantigrade foot, with the potential elimination of brace-wear for ambulation. The...

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Bibliographic Details
Published in:Foot & ankle international 2024-11, Vol.45 (11), p.1175-1183
Main Authors: Haupt, Edward Thomas, Porter, Giselle Moriah, Blough, Christian, Michalski, Max P., Pfeffer, Glenn B.
Format: Article
Language:English
Subjects:
Adult
Aged
Charcot-Marie-Tooth Disease - physiopathology
Charcot-Marie-Tooth Disease - surgery
Female
Humans
Male
Middle Aged
Plastic Surgery Procedures - methods
Retrospective Studies
Talipes Cavus - physiopathology
Talipes Cavus - surgery
Treatment Outcome
Young Adult
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Summary:Background: Charcot-Marie-Tooth (CMT) disease is a progressive inherited neurologic disorder causing muscle weakness and lower extremity deformity. The goal of foot and ankle surgical treatment is to create a stable, plantigrade foot, with the potential elimination of brace-wear for ambulation. The aim of this study was to report baseline CMT patient function and subsequent outcome improvement from surgical treatment, as determined by PROMIS physical function (PF), pain interference (PI), and mental health/depression (D) scores. Methods: Retrospective data were collected on consecutive CMT patients older than 18 years receiving surgical treatment by the senior surgeon at Cedars-Sinai Medical Center from 2018 to 2022 with minimum 1-year follow-up. Each patient prospectively completed PROMIS preoperatively and postoperatively after all planned surgical treatment was completed. Prospective clinical and radiographic data were collected to describe complications and correlation to outcome. Results: Ninety-five feet in 64 patients older than 18 years were included for analysis. Mean follow-up was 21 months (range, 12-31) with 100% minimum 1-year follow-up. CMT patients had worse preoperative and baseline scores in all domains except PROMIS-D compared with population normal PROMIS scores. Significant improvements were identified in all PROMIS domains following surgical treatment. The mean PROMIS-PF score increased (40 to 45, delta = 4.9, P 
ISSN:1071-1007
1944-7876
1944-7876
DOI:10.1177/10711007241271283