Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma

The sensitivity of currently available screening tools for urothelial carcinoma (UC) remains unsatisfactory particularly at early stages. Hence, we aimed to establish a novel blood-based screening tool for urothelial carcinoma. We measured serum d-amino acid levels in 108 and 192 patients with and w...

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Published in:Biochemical and biophysical research communications 2024-11, Vol.733, p.150701, Article 150701
Main Authors: Yamamoto, Akinaru, Kawashima, Atsunari, Sakai, Shinsuke, Mita, Masashi, Sassi, Nesrine, Inoguchi, Shunsuke, Horibe, Yuki, Yoshimura, Akihiro, Tani, Masaru, Yutong, Liu, Okuda, Yohei, Oka, Toshiki, Uemura, Toshihiro, Yamamichi, Gaku, Ishizuya, Yu, Hayashi, Takuji, Yamamoto, Yoshiyuki, Kato, Taigo, Hatano, Koji, Kakuta, Yoichi, Imamura, Ryoichi, Takahara, Shiro, Kimura, Tomonori, Nonomura, Norio
Format: Article
Language:English
Subjects:
Biomarker
Bladder cancer
d-amino acid
d-asparagine
Liquid biopsy
Urothelial carcinoma
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Summary:The sensitivity of currently available screening tools for urothelial carcinoma (UC) remains unsatisfactory particularly at early stages. Hence, we aimed to establish a novel blood-based screening tool for urothelial carcinoma. We measured serum d-amino acid levels in 108 and 192 patients with and without UC individuals in the derivation cohort, and 15 and 25 patients with and without UC in the validation cohort. Serum d-asparagine levels were significantly higher in patients with UC than in those without UC (p 
ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1016/j.bbrc.2024.150701