Efficacy of Double-Lumen Biliary-Enteric Tube in Enteral Nutrition for Patients with Malignant Obstructive Jaundice

This study aimed to evaluate the efficacy of a double-lumen biliary-enteric tube (DBET) for enteral nutrition (EN) in individuals with malignant obstructive jaundice (MOJ). A retrospective cohort study was conducted using data from a prospectively maintained single-center database, including patient...

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Published in:Nutrition and cancer 2025-01, Vol.77 (1), p.139-148
Main Authors: Cao, Jian-hua, Wu, Ke-fu, Li, Gao-xiang, Chen, Jie, Mu, Zhan-hu, Li, Hai-min, Yao, Jian-jun, Yang, Xue-wen
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Effectiveness
Enteral nutrition
Enteral Nutrition - methods
Female
Generalized linear models
Humans
Intubation, Gastrointestinal - methods
Jaundice
Jaundice, Obstructive - surgery
Jaundice, Obstructive - therapy
Male
Middle Aged
Mortality
Multivariable control
Nutrition
Nutritional status
Parenteral nutrition
Quality of life
Retrospective Studies
Statistical models
Stents
Treatment Outcome
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Summary:This study aimed to evaluate the efficacy of a double-lumen biliary-enteric tube (DBET) for enteral nutrition (EN) in individuals with malignant obstructive jaundice (MOJ). A retrospective cohort study was conducted using data from a prospectively maintained single-center database, including patients with MOJ. In the intervention group, DBET placement was performed concurrently with percutaneous transhepatic cholangiodrainage and biliary stenting, followed by postoperative EN (DBET-EN). In the control group, deep vein catheterization was undertaken after endoscopic biliary stenting, and parenteral nutrition (PN) was provided. A multivariable generalized linear model was used to assess the association between DBET-EN and 6-month mortality. A total of 74 patients were included in this study, comprising 28 patients in the intervention group (DBET-EN group) and 46 patients in the control group (PN group). Within the 6-month follow-up, 5 patients (17.9%) in the DBET-EN group and 20 (43.5%) in the PN group died. The multivariable generalized linear model demonstrated a significantly reduced 6-month mortality in the DBET-EN group compared to the PN group (adjusted odds ratio [OR]: 0.25, 95% CI: 0.08-0.81, P = 0.020). Secondary outcomes indicated that patients in the DBET-EN group had lower 9-month mortality rates and longer tube retention durations compared to the PN group (all adjusted P 
ISSN:0163-5581
1532-7914
1532-7914
DOI:10.1080/01635581.2024.2408041