Mood, Anxiety, and Cognitive Alterations in Cancer Patients

ABSTRACT Background and Objective To analyze the cytokine profile in cerebrospinal fluid (CSF), as well as mood, anxiety, and cognition profiles in patients with CC. Methods One hundred and nine individuals were evaluated, 37 controls, 18 CWC, and 54 CC patients. Assessments included BDI, HADS, Digi...

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Published in:Journal of surgical oncology 2024-09, Vol.130 (4), p.965-973
Main Authors: Fortes, Gabriela Noronha, Fortes, Marcos Fraga, Fortes, Marcos Noronha, Gomes, Fernanda Christoffel, Seelaendar, Marília Cerqueira Leite, Pinho, Ariene Murari Soares, Jesus, Joyce de Cassia Rosa, Otoch, José Pinhata
Format: Article
Language:English
Subjects:
Adult
Aged
Anxiety
Anxiety - etiology
cachexia
Cancer
Case-Control Studies
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - etiology
Cytokines
Cytokines - cerebrospinal fluid
Depression - etiology
Female
Humans
humor disorders
inflammation
Male
Middle Aged
neoplasia
Neoplasms - complications
Neoplasms - psychology
Quality of Life
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Summary:ABSTRACT Background and Objective To analyze the cytokine profile in cerebrospinal fluid (CSF), as well as mood, anxiety, and cognition profiles in patients with CC. Methods One hundred and nine individuals were evaluated, 37 controls, 18 CWC, and 54 CC patients. Assessments included BDI, HADS, Digit Span, FAS‐verbal, Animals/WMS‐R, Matrix Reasoning and Vocabulary (WASI), and QLQ‐C30. Results The CC group exhibited 62.96% depression and probable anxiety/depression, with 75.92% showing attention deficits. The CC and CWC groups demonstrated significant cognitive impairment on the WASI‐Vocabulary test (CWC: 13.4 ± 2.2; CC: 15.9 ± 1.1) compared to the control group (Ct: 22.8 ± 1.6; p = 0.0002). In the QLQ‐C30 scores, the CC group reported a greater perceived loss of quality of life and health deterioration (score of 17.5 ± 2.6) and lower scores on the Functional Scale (49.8 ± 4.5). The CC group had 18.52% illiteracy, 18.52% incomplete higher education, and 22.22% complete elementary education. The CC group also had lower weight (Ct: 67.8 ± 1.4; CWC: 61.7 ± 3.1; CC: 59.6 ± 1.7; p = 0.0023) and BMI (CC: 21.5 [18.3; 24.8]; Ct: 24.9 [23; 25.8]; p = 0.0021) compared to controls. Cytokines detected in the CSF were MCP‐1, VEGF, IL‐8, IP‐10, and MIP‐1β. Higher concentrations of MCP‐1 were found in cancer patients (CSC: 571.2 ± 105.8; CC: 399.5 ± 65.9; Ct: 1477 ± 0.1; p 
ISSN:0022-4790
1096-9098
1096-9098
DOI:10.1002/jso.27912