Protective effects of sodium humate on the intestinal barrier damage of Salmonella Typhimurium‐challenged broilers

• Published in: Animal science journal 2024-01, Vol.95 (1), p.e14004-n/a
• Main Authors: Ma, Weiming, Zou, Xing, Sun, Xinyu, Wang, Wenzhe, Liu, Kexin, He, Yanjun, Liu, Yun, Wang, Dong
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants - metabolism; Body weight; broiler; Catalase; Catalase - metabolism; Chickens - microbiology; Claudin-1 - metabolism; Cytokines - metabolism; Damage; Immunoglobulin A; Immunoglobulin A, Secretory - metabolism; Inflammation Mediators - metabolism; intestinal inflammation; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestine; Intestines - microbiology; NF-kappa B - metabolism; Occludin - metabolism; Poultry Diseases - microbiology; Poultry Diseases - prevention & control; Salmonella; Salmonella Infections, Animal - microbiology; Salmonella Infections, Animal - prevention & control; Salmonella Typhimurium; Signal Transduction; Sodium; sodium humate; Superoxide dismutase; Superoxide Dismutase - metabolism; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Up-Regulation; Villus; Zonula Occludens-1 Protein - metabolism
• ISSN: 1344-3941; 1740-0929; 1740-0929
• DOI: 10.1111/asj.14004

Salmonella Typhimurium (S. Typhimurium) infections can lead to severe intestinal damage and reduce growth performance in broilers. Thus, this study examined the potential mitigating impact of sodium humate (HNa) on intestinal barrier damage resulting from S. Typhimurium infection in broilers. A total of 320 1‐day‐old Arbor Acres broilers were randomly assigned into 5 treatments with 8 replicates. On d 22–24, broilers in the CON group were challenged with 1 ml of PBS, while broilers in the other groups were challenged with 1 ml of 3 × 109 CFU/ml S. Typhimurium, daily. Dietary administration with 4 g/kg of HNa increased (P