Correlation Between Osteoporosis and Endplate Damage in Degenerative Disc Disease Patients: A Study Based on Phantom-Less Quantitative Computed Tomography and Total Endplate Scores

• Published in: World neurosurgery 2024-12, Vol.192, p.e347-e354
• Main Authors: Zhang, Yiming, Dou, Yiming, Weng, Yuanzhi, Chen, Chao, Zhao, Qingqian, Wan, Wentao, Bian, Hanming, Tian, Ye, Liu, Yang, Zhu, Shan, Wang, Zhi, Ma, Xinlong, Liu, Xinyu, Lu, Weijia William, Yang, Qiang
• Format: Article
• Language: English
• Subjects: Adult; Aged; Bone Density; Degenerative disc disease; Endplate damage; Female; Humans; Intervertebral Disc Degeneration - diagnostic imaging; Lumbar Vertebrae - diagnostic imaging; Male; Middle Aged; Osteoporosis; Osteoporosis - complications; Osteoporosis - diagnostic imaging; Phantom-less quantitative computed tomography; Retrospective Studies; Tomography, X-Ray Computed; Total endplate scores; Volumetric bone mineral density
• ISSN: 1878-8750; 1878-8769; 1878-8769
• DOI: 10.1016/j.wneu.2024.09.100

Osteoporosis and degenerative disc disease (DDD) are prevalent in the elderly population. Damage to the vertebral endplate, which impairs nutrient supply to the disc, serves as both a significant initiator and a hallmark of DDD. This study was aimed to explore the association between osteoporosis and endplate damage. This retrospective study included 205 patients with DDD who were treated at Tianjin Hospital from January 2019 to May 2023. We collected data on age, sex, body mass index, phantom-less quantitative computed tomography (PL-QCT) values, and total endplate scores (TEPS). The average PL-QCT value of L1–L4 and TEPS were used to represent volumetric bone mineral density (BMD) and the degree of endplate damage, respectively. Based on the average PL-QCT value of L1 and L2, patients were divided into 3 groups: normal group (BMD > 120 mg/cm3), osteopenic group (80 mg/cm3 ≤ BMD ≤ 120 mg/cm3), and osteoporosis group (BMD < 80 mg/cm3). Multiple linear regression models were used to identify independent factors associated with endplate damage. The overall TEPS (4.3 ± 1.3 vs. 5.0 ± 1.0 vs. 5.9 ± 1.5, P < 0.01) and segment (L1/2–L4/5) TEPS (P < 0.05) in each group showed significant difference (R = −0.5), increasing in order from normal group to osteoporosis group. A significant negative correlation was found between TEPS and PL-QCT values in overall and each segment (P < 0.001). The PL-QCT values and age (P < 0.05) were independent factors influencing endplate damage. There were significant differences in the average number of TEPS ≥7 segments per patient among the 3 groups, with 1.16, 0.41, and 0.2 segments/person from osteoporosis group to normal group. Our study showed a significant positive correlation between osteoporosis and endplate damage. Attention is warranted for patients with osteopenia to prevent progression to osteoporosis, potentially leading to exacerbated DDD. The management of patients with both DDD and osteoporosis necessitates comprehensive treatment strategies that address both the BMD and endplate aspects of these conditions.