Evaluation of the Effect of Dibornol on the Level of DNA Damage in the DNA Comet Test In Vivo

In male C57BL/6 mice (8-12 weeks) and male Wistar rats (12 weeks), the effect of dibornol (2,6-diisobornyl-4-methylphenol) on the level of spontaneous DNA damage in cells of the bone marrow, liver, kidneys, and rectum of mice (series I) and genotoxic effects in rat testicular cells after administrat...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2024-09, Vol.177 (5), p.635-638
Main Authors: Borovskaya, T. G., Vychuzhanina, A. V., Schemerova, Yu. A., Stremlina, L. A., Chukicheva, I. Yu, Kuchin, A. V., Goldberg, V. E., Dygai, A. M.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Bone marrow
Bone Marrow - drug effects
Camphanes - pharmacology
Cell Biology
Comet assay
Comet Assay - methods
Cresols
DNA damage
DNA Damage - drug effects
Doxorubicin
Doxorubicin - pharmacology
Doxorubicin - toxicity
Drug dosages
Genotoxicity
Hepatocytes
Internal Medicine
Kidney - drug effects
Laboratory Medicine
Liver - drug effects
Male
Methotrexate
Methotrexate - pharmacology
Methotrexate - toxicity
Mice
Mice, Inbred C57BL
Pathology
Rats
Rats, Wistar
Rectum - drug effects
Rectum - pathology
Testis - drug effects
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Summary:In male C57BL/6 mice (8-12 weeks) and male Wistar rats (12 weeks), the effect of dibornol (2,6-diisobornyl-4-methylphenol) on the level of spontaneous DNA damage in cells of the bone marrow, liver, kidneys, and rectum of mice (series I) and genotoxic effects in rat testicular cells after administration of cytostatic drugs with different mechanisms of action (series II) were studied using the DNA comet assay. In series I, dibornol was intragastrically administered to mice once at doses of 200, 400, and 2000 mg/kg; in series II, dibornol was intragastrically administered to rats at a dose of 10 mg/kg for 5 days before and 5 days after the cytostatic treatment (methotrexate, doxorubicin). It was found that dibornol in all studied doses did not produce the genotoxic (carcinogenic) effect and reduced the level of spontaneous DNA damage in the bone marrow. After combined administration of cytostatic drugs (doxorubicin, methotrexate) and dibornol, the level of DNA breaks was reduced to 38.5 and 49% of the control, respectively.
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06239-0