Changes in Innate Immunity and Microbiome in Different Aging Phenotypes

• Published in: Bulletin of experimental biology and medicine 2024-09, Vol.177 (5), p.658-661
• Main Authors: Gankovskaya, L. V., Svitich, O. A., Poddubikov, A. V., Burmakina, V. V., Khasanova, E. M., Gorodishchenskaya, S. V.
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Aging; Aging - genetics; Aging - immunology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell cycle; Centenarians; Cytokines; Female; Gene expression; Genotype & phenotype; Geriatrics; Humans; IL-1β; Immune system; Immunity (Disease); Immunity, Innate - genetics; Inflammation; Innate immunity; Interleukin 18; Interleukin-18 - genetics; Interleukin-18 - metabolism; Interleukin-1beta - genetics; Interleukin-1beta - immunology; Interleukin-1beta - metabolism; Internal Medicine; Laboratory Medicine; Male; Membranes; Microbiomes; Microbiota; Microbiota - genetics; Microbiota - immunology; Microorganisms; Mucosal immunity; Nasopharynx - immunology; Nasopharynx - microbiology; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Older people; Oldest old people; Pathology; Pattern recognition; Phenotype; Phenotypes; TLR2 protein; TLR4 protein; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - immunology; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Veterans
• ISSN: 0007-4888; 1573-8221; 1573-8221
• DOI: 10.1007/s10517-024-06244-3

The indicators of innate immunity and the composition of the microbiome in the nasopharyngeal mucosa in centenarians with different aging phenotypes were analyzed. A significant increase in the expression of pattern-recognizing receptor genes ( TLR2 , TLR4 , and NLRP3 ) and proinflammatory cytokines ( IL1B , IL18 ) was shown in the group of centenarians with pathological aging phenotype. In centenarians with successful aging phenotype, increased diversity of the microbiome composition was observed. At the same time, a moderate inverse correlation was found between an increase in the growth of the commensal bacterium Streptococcus salivarius and a decrease in the expression of proinflammatory cytokine genes IL1B and IL18 . These findings can serve as biomarkers for the timely identification of the phenotype of aging in senile and elderly people.