Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP

The COVID-19 pandemic has underscored the critical importance of understanding the intricate relationship between micronutrient levels and disease outcomes. This study explores the impact of Vitamin D, calcium, phosphorus, magnesium, and alkaline phosphatase (ALP) on COVID-19 severity and mortality....

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of clinical biochemistry 2024-10, Vol.39 (4), p.548-556
Main Authors: Kumar, PVSN Kiran, Japa, Pradeep, Tomo, Sojit, Sankanagoudar, Shrimanjunath, Purohit, Purvi, Charan, Jayakaran, Purohit, Abhishek, Nag, Vijaya Lakshmi, Bhatia, Pradeep Kumar, Singh, Kuldeep, Dutt, Naveen, Garg, Mahendra Kumar, Misra, Sanjeev, Sharma, Praveen, Yadav, Dharamveer
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Biochemistry
Biomedical and Life Sciences
Calcium signalling
Chemistry/Food Science
Clinical trials
COVID-19
Life Sciences
Magnesium
Microbiology
Micronutrients
Mortality
Original Research Article
Pathology
Phosphorus
Vitamin D
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The COVID-19 pandemic has underscored the critical importance of understanding the intricate relationship between micronutrient levels and disease outcomes. This study explores the impact of Vitamin D, calcium, phosphorus, magnesium, and alkaline phosphatase (ALP) on COVID-19 severity and mortality. The study involves 200 participants (100 COVID-19 patients, 100 controls), we meticulously analyzed micronutrient dynamics. Calcium, phosphorus, magnesium and ALP was measured spectrophotometrically. Vitamin D was measured using Chemiluminescent method. The study reveals that diminished levels of calcium, phosphorus, magnesium, and with elevated ALP, are significantly associated with COVID-19 cases. Whereas the Vitamin D levels in severe group was increased when compared to mild cases but decreased than control group. Disease severity correlated with declining calcium (r = − 0.35, p  
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-024-01225-9