Pregnancy cholestasis typically occurs in the third trimester of pregnancy and is a significant clinical condition

Aim The aim of this study is to determine the albumin/bilirubin ratio index and the aspartate aminotransferase (AST)/alanine aminotransferase ratio (ALT) index in patients diagnosed with cholestasis during pregnancy, and to demonstrate their correlation with liver damage. Additionally, potential str...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2024-11, Vol.310 (5), p.2531-2539
Main Authors: Küçükyurt, Ayça Kubat, Atakul, Nil, Solak, Yağmur
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Bilirubin - blood
Case-Control Studies
Cholestasis - blood
Cholestasis - diagnosis
Endocrinology
Female
Gallbladder diseases
Gynecology
Human Genetics
Humans
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - diagnosis
Pregnancy Trimester, Third - blood
Retrospective Studies
Serum Albumin - analysis
Turkey - epidemiology
Womens health
Young Adult
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Summary:Aim The aim of this study is to determine the albumin/bilirubin ratio index and the aspartate aminotransferase (AST)/alanine aminotransferase ratio (ALT) index in patients diagnosed with cholestasis during pregnancy, and to demonstrate their correlation with liver damage. Additionally, potential strategies to prevent liver damage will be elucidated. Materials and method Our study is a retrospective study. A total of 4019 pregnant women aged between 18 and 40 years, presenting with itching complaints at 32–36 weeks of gestation, were screened at the Department of Obstetrics and Gynecology, Istanbul Training and Research Hospital of Health Sciences University between January 1, 2018, and December 31, 2023. Among them, 104 pregnant women without any other accompanying diseases were diagnosed with Gestational Cholestasis. Among the 104 diagnosed women, 78 met the inclusion criteria and were included in the study. Twenty-six women were excluded from the study due to missing albumin and total bilirubin values or due to blood samples being taken at different times. The serum albumin/bilirubin ratio index and the alanine aminotransferase/aspartate aminotransferase ratio index were calculated and statistically compared between pregnant women diagnosed with cholestasis and healthy pregnant women at the same gestational week. Findings We found that AST, ALT, albumin, and total bilirubin levels were significantly higher in pregnant women diagnosed with cholestasis compared to the control group ( p  
ISSN:1432-0711
0932-0067
1432-0711
DOI:10.1007/s00404-024-07736-3