Magnesium-promoted nickel-catalysed chlorination of aryl halides and triflates under mild conditions

In this study, we present a ligand-free nickel (II) -catalyzed halogen exchange of aromatic halides with magnesium chloride. This method effectively facilitates the retro -Finkelstein reaction for a wide range of aryl bromides, iodides and triflates, demonstrating excellent functional group toleranc...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-10, Vol.6 (84), p.12213-12216
Main Authors: Zhang, Tian-Yu, Bilal, Muhammad, Wang, Tian-Zhang, Zhang, Chao-Peng, Liang, Yu-Feng
Format: Article
Language:English
Subjects:
Aromatic compounds
Bromides
Functional groups
Halides
Magnesium chloride
Nickel
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Summary:In this study, we present a ligand-free nickel (II) -catalyzed halogen exchange of aromatic halides with magnesium chloride. This method effectively facilitates the retro -Finkelstein reaction for a wide range of aryl bromides, iodides and triflates, demonstrating excellent functional group tolerance. Mechanistic studies reveal that magnesium plays a crucial role in the challenging reductive elimination from Ni (II) intermediates. Nickel-catalysed chlorination of aryl halides and triflates has been developed with magnesium chloride, which promoted the challenging reductive elimination from Ni( ii ) intermediates.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc04383a