Factors influencing metal concentrations in hair and nails during longitudinal follow-up of apprentice welders

• Published in: Journal of Toxicology and Environmental Health, Part A Part A, 2024-12, Vol.87 (24), p.1030-1049
• Main Authors: Buitrago-Cortes, Jairo, Sarazin, Philippe, Dieme, Denis, El Majidi, Naïma, Bouchard, Michèle
• Format: Article
• Language: English
• Subjects: Adult; apprentice welders; Arsenic; Barium; Biological effects; Biomarkers; Biomarkers - analysis; Biomarkers - metabolism; Biomonitoring; Chromium; Cobalt; Curricula; Exposure; Female; Fingernail; Fingers & toes; Follow-Up Studies; Hair; Hair - chemistry; Heavy metals; Humans; Longitudinal Studies; Male; Manganese; Metal concentrations; Metal workers; metals; Metals - analysis; Middle Aged; nails; Nails - chemistry; Nickel; Occupational Exposure - analysis; Quebec; Temporal variations; Time measurement; Toenail; Vanadium; Welding; welding fume exposure; Welding machines; Young Adult
• ISSN: 1528-7394; 1087-2620; 2381-3504
• DOI: 10.1080/15287394.2024.2410283

The aim of this study was to determine factors influencing observed increased metal biomarkers of exposure levels in a group of 116 Quebec apprentice welders during a longitudinal follow-up of exposure. Analysis of 14 metals was carried out in hair, fingernail, and toenail samples taken from participants over the course of their welding curriculum at 6 different times. Personal and socio-demographic characteristics, lifestyle habits, and other potential confounding factors were documented by questionnaire. Multivariate linear mixed-effect models were used to assess main predictors of metal concentrations in each biological matrix including increasing time of exposure throughout the curriculum (defined as the repeated measure "time" variable"). Significant associations between repeated measure "time" variable and metal levels in hair, fingernails, and toenails were found for chromium, iron, manganese and nickel. Significant associations with "time" were also noted for arsenic levels in hair and fingernails, and for barium, cobalt and vanadium levels in fingernails and toenails. The repeated measure "time" variable, hence increasing time of exposure throughout the curriculum, was the predominant predictor of elevated biological metal levels. Reduced spaces and simultaneous activities such as oxyfuel-cutting and welding in the same welding room were suspected to contribute to higher metal levels. Age, ethnicity, and annual household income exerted an effect on metal levels and considered as confounders in the models. Variations observed in metal levels between hair and nails of apprentice welders also emphasized the relevance and importance of performing multi-matrix and multi-element biomonitoring to assess temporal variations in biological metal concentrations during welding curriculum.