Hybrid protein filaments are a surprise twist in neurodegeneration

Abnormal filaments of a single type of protein are hallmarks of neurodegeneration. Structural studies reveal filaments made from two discrete but interwoven proteins, giving clues about the origin of neurodegenerative conditions. Proteins TDP-43 and ANXA11 form hybrid filaments in neurons.

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Bibliographic Details
Published in:Nature (London) 2024-10, Vol.634 (8034), p.550-551
Main Authors: Fernandopulle, Michael S., Ward, Michael E.
Format: Article
Language:English
Subjects:
631/1647/328
631/535
692/699/375/364
Animals
Humanities and Social Sciences
Humans
Mice
multidisciplinary
Nerve Degeneration - metabolism
Nerve Degeneration - pathology
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
News And Views
Science
Citations: Items that this one cites
Online Access:Get full text
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Description
Summary:Abnormal filaments of a single type of protein are hallmarks of neurodegeneration. Structural studies reveal filaments made from two discrete but interwoven proteins, giving clues about the origin of neurodegenerative conditions. Proteins TDP-43 and ANXA11 form hybrid filaments in neurons.
ISSN:0028-0836
1476-4687
1476-4687
DOI:10.1038/d41586-024-03054-5