The Multifaceted Roles of Hippo-YAP in Cardiovascular Diseases

The Hippo-yes-associated protein (YAP) signaling pathway plays a crucial role in cell proliferation, differentiation, and death. It is known to have impact on the progression and development of cardiovascular diseases (CVDs) as well as in the regeneration of cardiomyocytes (CMs). However, further re...

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Bibliographic Details
Published in:Cardiovascular toxicology 2024-12, Vol.24 (12), p.1410-1427
Main Authors: Wu, Hao, Che, Yan-Nan, Lan, Qi, He, Yi-Xiang, Liu, Ping, Chen, Ming-Tai, Dong, Li, Liu, Meng-Nan
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Animals
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cardiology
Cardiomyocytes
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cardiovascular Diseases - physiopathology
Cell death
Cell differentiation
Cell growth
Cell Proliferation
Chinese medicine
Congestive heart failure
Connective tissue
Coronary vessels
Cytoskeleton
Extracellular matrix
Fatalities
Growth factors
Heart attacks
Heart failure
Hippo Signaling Pathway
Humans
Insects
Ischemia
Kinases
Molecular modelling
Myocardial infarction
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Pharmacology/Toxicology
Phosphorylation
Protein Serine-Threonine Kinases - metabolism
Proteins
Regeneration
Review
Roles
Signal Transduction
Toxicology
Transcription factors
Transcription Factors - metabolism
Vein & artery diseases
YAP-Signaling Proteins - metabolism
Yes-associated protein
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Description
Summary:The Hippo-yes-associated protein (YAP) signaling pathway plays a crucial role in cell proliferation, differentiation, and death. It is known to have impact on the progression and development of cardiovascular diseases (CVDs) as well as in the regeneration of cardiomyocytes (CMs). However, further research is needed to understand the molecular mechanisms by which the Hippo-YAP pathway affects the pathological processes of CVDs in order to evaluate its potential clinical applications. In this review, we have summarized the recent findings on the role of the Hippo-YAP pathway in CVDs such as myocardial infarction, heart failure, and cardiomyopathy, as well as its in CM development. This review calls attention to the potential roles of the Hippo-YAP pathway as a relevant target for the future treatment of CVDs.
ISSN:1530-7905
1559-0259
1559-0259
DOI:10.1007/s12012-024-09926-6