SARIFA-a new multi-entity biomarker

A stroma a‑reactive invasion front area (SARIFA) is a new prognostic biomarker in carcinomas. Essentially, SARIFA describes the occurrence of direct contact between at least five tumor cells and adipocytes. This phenomenon is extremely easy and quick to identify, shows an extremely low interobserver...

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Bibliographic Details
Published in:Pathologie (Heidelberg, Germany) Germany), 2024-11, Vol.45 (6), p.397
Main Authors: Grosser, Bianca, Reitsam, Nic G, Grochowski, Przmyslaw, Rentschler, Lukas, Enke, Johanna, Märkl, Bruno
Format: Article
Language:ger
Subjects:
Adipocytes - metabolism
Adipocytes - pathology
Biomarkers, Tumor - metabolism
Humans
Neoplasm Invasiveness
Neoplasms - diagnosis
Neoplasms - pathology
Prognosis
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Description
Summary:A stroma a‑reactive invasion front area (SARIFA) is a new prognostic biomarker in carcinomas. Essentially, SARIFA describes the occurrence of direct contact between at least five tumor cells and adipocytes. This phenomenon is extremely easy and quick to identify, shows an extremely low interobserver variability, and does not require any additional staining as it can be identified on standard HE sections. The prognostic efficiency has now been demonstrated in gastric, colorectal, pancreatic, and prostate carcinoma.
ISSN:2731-7196
2731-7196
DOI:10.1007/s00292-024-01368-9